Boyd A L, Jones J M
Toxicol Lett. 1986 Mar;30(3):253-8. doi: 10.1016/0378-4274(86)90163-3.
Treatment with dioctyltin dichloride (DOTC) induced increased mortality, atrophy of the thymus and suppression of responses to concanavalin A. Brown Norway (BN) rats were more susceptible than Lewis (LEW) to the lethal effects of DOTC and males were more susceptible than females. Increased mortality did not correlate with changes in the histological appearance of the thymus. LEW X BN F1 hybrids resembled the LEW parent in susceptibility to the lethal effects of DOTC and the BN parent in susceptibility to changes in the thymus.
用二氯化二辛基锡（DOTC）处理会导致死亡率增加、胸腺萎缩以及对刀豆球蛋白A的反应受到抑制。棕色挪威（BN）大鼠比刘易斯（LEW）大鼠对DOTC的致死作用更敏感，且雄性比雌性更敏感。死亡率增加与胸腺组织学外观的变化无关。LEW×BN F1杂种在对DOTC致死作用的易感性方面类似于LEW亲本，而在对胸腺变化的易感性方面类似于BN亲本。
