Olah I, Glick B
Anat Rec. 1986 Apr;214(4):398-404. doi: 10.1002/ar.1092140410.
Bursal secretory cells have been studied with light and electron microscope after prolonged carrageenan treatment. Intravenous injected carrageenan decreased the number of secretory cells as early as 4 days after the first carrageenan administration. Degranulation of the secretory cells may have made it difficult to identify these cells. The discharge of granules from the secretory cells was indicated by the appearance of a large amount of extracellular substance on the cell surface. The carrageenan may have accelerated the IgM-IgG switch after immunization with Salmonella O antigen. The rapid IgM-IgG switch was preceded by degranulations of the secretory cells. Therefore, the secretory products of the cells might have contributed to the switch. The number of secretory cells in the carrageenan-treated birds increased by the secondary immunization. Many of these secretory cells were immature and located close to the corticomedullary border. The young cells revealed a large blastlike nucleus and bulky cytoplasm with granules surrounding the cytocentrum and Golgi zone.
在长期给予角叉菜胶处理后，已用光镜和电镜对法氏囊分泌细胞进行了研究。静脉注射角叉菜胶后，早在首次给予角叉菜胶4天后，分泌细胞的数量就减少了。分泌细胞的脱颗粒可能使其难以识别。细胞表面出现大量细胞外物质表明分泌细胞的颗粒已排出。角叉菜胶可能在用沙门氏菌O抗原免疫后加速了IgM-IgG转换。快速的IgM-IgG转换之前是分泌细胞的脱颗粒。因此，细胞的分泌产物可能促成了这种转换。经角叉菜胶处理的禽类经二次免疫后，分泌细胞的数量增加。这些分泌细胞中的许多都不成熟，位于皮质髓质边界附近。这些年轻细胞显示出一个大的母细胞样核和体积较大的细胞质，颗粒围绕着细胞中心体和高尔基体区域。
