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神经感觉假肢:生物电子设备中不可或缺的神经调节部分。

Neurosensory Prosthetics: An Integral Neuromodulation Part of Bioelectronic Device.

作者信息

Ezeokafor Ifeoma, Upadhya Archana, Shetty Saritha

机构信息

Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, Shri Vile Parle Kelavani Mandal (SVKM) Narsee Monjee Institute of Management Studies (NMiMS) (SVKM'S NMiMS), Mumbai, India.

出版信息

Front Neurosci. 2021 Nov 16;15:671767. doi: 10.3389/fnins.2021.671767. eCollection 2021.

Abstract

Bioelectronic medicines (BEMs) constitute a branch of bioelectronic devices (BEDs), which are a class of therapeutics that combine neuroscience with molecular biology, immunology, and engineering technologies. Thus, BEMs are the culmination of thought processes of scientists of varied fields and herald a new era in the treatment of chronic diseases. BEMs work on the principle of neuromodulation of nerve stimulation. Examples of BEMs based on neuromodulation are those that modify neural circuits through deep brain stimulation, vagal nerve stimulation, spinal nerve stimulation, and retinal and auditory implants. BEDs may also serve as diagnostic tools by mimicking human sensory systems. Two examples of BEDs used as diagnostic agents in biomedical applications based on neurosensory circuits are the bioelectronic nose and bioelectronic tongue. The review discusses the ever-growing application of BEDs to a wide variety of health conditions and practices to improve the quality of life.

摘要

生物电子药物(BEMs)是生物电子设备(BEDs)的一个分支,生物电子设备是一类将神经科学与分子生物学、免疫学及工程技术相结合的疗法。因此,生物电子药物是不同领域科学家思维过程的结晶,开创了慢性病治疗的新纪元。生物电子药物基于神经刺激的神经调节原理发挥作用。基于神经调节的生物电子药物实例包括那些通过深部脑刺激、迷走神经刺激、脊髓神经刺激以及视网膜和听觉植入来改变神经回路的药物。生物电子设备还可以通过模仿人类感官系统用作诊断工具。基于神经感觉回路在生物医学应用中用作诊断剂的生物电子设备的两个实例是生物电子鼻和生物电子舌。这篇综述讨论了生物电子设备在改善生活质量的各种健康状况和实践中的应用不断增加的情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4d5/8637173/ec17c21473e9/fnins-15-671767-g001.jpg

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