Zambom-Ferraresi Fabíola, Zambom-Ferraresi Fabricio, Fernández-Irigoyen Joaquín, Lachén-Montes Mercedes, Cartas-Cejudo Paz, Lasarte Juan José, Casares Noelia, Fernández Secundino, Cedeño-Veloz Bernardo Abel, Maraví-Aznar Enrique, Uzcanga-Lacabe Maria Itziar, Galbete Arkaitz, Santamaría Enrique, Martínez-Velilla Nicolás
Geriatric Unit, Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IdisNa), Pamplona, Spain.
Clinical Neuroproteomics Unit, Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IdisNa), Pamplona, Spain.
Front Aging Neurosci. 2021 Nov 16;13:757081. doi: 10.3389/fnagi.2021.757081. eCollection 2021.
The aim of this article is to present the research protocol for a prospective cohort study that will assess the olfactory function and the effect of an intervention based on olfactory training in healthy very old adults (≥75 years old). A convenience sample of 180 older people (50% female) will be recruited in three different environments: hospitalized control group (CH) with stable acute illness ( = 60); ambulatory control group (CA) of community-based living ( = 60); and an experimental odor training group (EOT) from nursing homes ( = 60). The odor training (OT) intervention will last 12 weeks. All the volunteers will be assessed at baseline; CA and EOT groups will also be assessed after 12 weeks. The primary end point will be change in olfactory capacity from baseline to 12 weeks period of intervention or control. The intervention effects will be assessed with the overall score achieved in Sniffin Sticks Test (SST) - Threshold, Discrimination, and Identification (TDI) extended version. Secondary end points will be changes in cognitive tasks, quality of life, mood, immune status, and functional capacity. All these measurements will be complemented with an immune fitness characterization and a deep proteome profiling of the olfactory epithelium (OE) cultured . The current study will provide additional evidence to support the implementation of olfactory precision medicine and the development of immunomodulatory nasal therapies based on non-invasive procedures. The proposed intervention will also intend to increase the knowledge about the olfactory function in very elderly people, improve function and quality of life, and promote the recovery of the health.
本文旨在介绍一项前瞻性队列研究的研究方案，该研究将评估健康的高龄成年人（≥75岁）的嗅觉功能以及基于嗅觉训练的干预措施的效果。将在三种不同环境中招募180名老年人（50%为女性）的便利样本：患有稳定急性疾病的住院对照组（CH，n = 60）；社区生活的非住院对照组（CA，n = 60）；以及来自养老院的实验性气味训练组（EOT，n = 60）。气味训练（OT）干预将持续12周。所有志愿者将在基线时进行评估；CA组和EOT组还将在12周后进行评估。主要终点将是从基线到12周干预或对照期嗅觉能力的变化。干预效果将通过嗅觉棒测试（SST）-阈值、辨别和识别（TDI）扩展版获得的总分来评估。次要终点将是认知任务、生活质量、情绪、免疫状态和功能能力的变化。所有这些测量将辅以免疫健康特征分析和培养的嗅觉上皮（OE）的深度蛋白质组分析。本研究将提供额外证据，以支持嗅觉精准医学的实施以及基于非侵入性程序的免疫调节性鼻腔疗法的开发。拟议的干预措施还旨在增加对高龄人群嗅觉功能的了解，改善功能和生活质量，并促进健康恢复。
