Xie Yingqi, Wang Shenglei, Cha Xudong, Li Fengzhen, Xu Zengyi, Wu Jian, Liu Huanhai, Ren Wenwen
Department of Otolaryngology, The Second Affiliated Hospital of the Naval Medical University, Shanghai Changzheng Hospital, Shanghai, China.
Cell Mol Life Sci. 2025 May 13;82(1):199. doi: 10.1007/s00018-025-05637-5.
Olfactory dysfunction (OD) is a common nasal disease, particularly prevalent among the elderly population, significantly impacting the affected individuals' quality of life. This review focuses on the influence of aging and chronic inflammation on olfactory dysfunction, presenting insights from both the peripheral and central olfactory systems. By exploring the molecular mechanisms and pathological changes underlying the occurrence of olfactory dysfunction in relation to age-related diseases and chronic inflammation conditions, we aim to provide a comprehensive theoretical foundation for further research and offer valuable insights for more effective treatment of olfactory dysfunction.
嗅觉功能障碍（OD）是一种常见的鼻腔疾病，在老年人群中尤为普遍，严重影响患者的生活质量。本综述重点关注衰老和慢性炎症对嗅觉功能障碍的影响，介绍来自外周和中枢嗅觉系统的见解。通过探讨与年龄相关疾病和慢性炎症状况相关的嗅觉功能障碍发生的分子机制和病理变化，我们旨在为进一步研究提供全面的理论基础，并为更有效地治疗嗅觉功能障碍提供有价值的见解。
