Ebersole J L, Taubman M A, Smith D J
Cell Immunol. 1983 Apr 15;77(2):372-84. doi: 10.1016/0008-8749(83)90038-2.
IgA responses in submandibular salivary glands, cervical lymph nodes, and saliva of rats were studied. Immunoglobulin-containing cells of the IgA isotype were examined by immunofluorescence of mononuclear cells isolated from the submandibular salivary glands and cervical lymph nodes after primary and multiple local injections of Streptococcus mutans. Also, salivary and serum antibodies to S. mutans were determined using an ELISA. The results support immunologic memory for the secretory (salivary) IgA system at both the cellular and humoral levels. Comparison of the dynamics of the IgAICC responses among the tissues and secretions after the injection regimes suggests that the cervical lymph nodes may provide an enriched tissue source for secretory IgA responses in the oral cavity.
对大鼠下颌下唾液腺、颈部淋巴结和唾液中的IgA反应进行了研究。在初次和多次局部注射变形链球菌后，通过对从下颌下唾液腺和颈部淋巴结分离的单核细胞进行免疫荧光检查，来检测IgA同种型的含免疫球蛋白细胞。此外，使用酶联免疫吸附测定法测定唾液和血清中针对变形链球菌的抗体。结果支持了分泌型（唾液）IgA系统在细胞和体液水平上的免疫记忆。注射方案后各组织和分泌物中IgAICC反应动态的比较表明，颈部淋巴结可能为口腔中分泌型IgA反应提供丰富的组织来源。
