大鼠胸腺对分泌性抗体应答的调控。
Thymic control of secretory antibody responses in the rat.
作者信息
Ebersole J L, Taubman M A, Smith D J
出版信息
J Immunol. 1979 Jul;123(1):19-24.
The effect of neonatal thymectomy on salivary and serum antibody responses was studied in rats. Local immunization of thymectomized rats with a T-dependent antigen (DNPBGG) elicited negligible amounts of IgA anti-DNP antibody in saliva. In contrast, both normal and sham-thymectomized animals demonstrated substantial levels of salivary IgA antibody. All thymectomized rats locally injected with a T-independent antigen (DNP-Lys-Ficoll) exhibited salivary IgA antibody production. Salivary IgG antibodies were somewhat decreased in thymectomized rats injected with either antigen; however, the final effect of T cell deprivation on IgG synthesis was not as pronounced as on IgA synthesis. Serum IgA antibody was induced in control rats injected with DNPBGG, whereas this Ig class of antibody was absent in thymectomized rats. The results suggest that thymus-derived cells exert a regulatory influence on both serum and secretory IgA responses to antigens.
在大鼠中研究了新生期胸腺切除对唾液和血清抗体反应的影响。用T细胞依赖性抗原（二硝基苯偶联卵清蛋白，DNPBGG）对胸腺切除的大鼠进行局部免疫，在唾液中诱导出的IgA抗二硝基苯抗体量可忽略不计。相比之下，正常和假胸腺切除的动物唾液中IgA抗体水平都很高。所有局部注射T细胞非依赖性抗原（二硝基苯-赖氨酸-聚蔗糖，DNP-Lys-Ficoll）的胸腺切除大鼠都产生了唾液IgA抗体。注射任何一种抗原的胸腺切除大鼠唾液IgG抗体都有所减少；然而，T细胞缺失对IgG合成的最终影响不如对IgA合成那么明显。注射DNPBGG的对照大鼠诱导出了血清IgA抗体，而胸腺切除的大鼠中没有这类抗体。结果表明，胸腺来源的细胞对血清和分泌性IgA对抗原的反应发挥调节作用。
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