• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Comparison of in vivo and in vitro multiplication rates of Haemophilus influenzae type b.b型流感嗜血杆菌体内和体外增殖率的比较
Infect Immun. 1986 Jun;52(3):911-3. doi: 10.1128/iai.52.3.911-913.1986.
2
Haemophilus influenzae b infection in rats: effect of splenectomy on bloodstream and meningeal invasion after intravenous and intranasal inoculations.大鼠B型流感嗜血杆菌感染：脾切除对静脉内和鼻内接种后血流及脑膜侵袭的影响
Infect Immun. 1980 Mar;27(3):872-5. doi: 10.1128/iai.27.3.872-875.1980.
3
Anticapsular antibody requirements for protection against experimental Haemophilus influenzae type b bacteremia after splenectomy.脾切除术后预防实验性b型流感嗜血杆菌菌血症所需的抗荚膜抗体
Infect Immun. 1988 Apr;56(4):984-6. doi: 10.1128/iai.56.4.984-986.1988.
4
[Comparative study of the protective role of the vaccine against Haemophilus influenzae type b and partial splenectomy in an experimental model].[在实验模型中对b型流感嗜血杆菌疫苗和部分脾切除术的保护作用的比较研究]
Enferm Infecc Microbiol Clin. 1997 Jan;15(1):5-9.
5
Pathogenesis of bloodstream invasion with Haemophilus influenzae type b.b型流感嗜血杆菌血流侵袭的发病机制。
Infect Immun. 1983 Jul;41(1):280-4. doi: 10.1128/iai.41.1.280-284.1983.
6
Comparison of the Du Pont Isolator 1.5 Microbial Tube and Trypticase soy broth for the recovery of Haemophilus influenzae type b in experimental bacteremia.在实验性菌血症中比较杜邦隔离器1.5微生物管和胰蛋白胨大豆肉汤对b型流感嗜血杆菌的回收率。
J Clin Microbiol. 1985 Nov;22(5):815-8. doi: 10.1128/jcm.22.5.815-818.1985.
7
[Brazilian purpuric fever, virulence in an animal model of Haemophilus aegyptius (H. influenzae biogroup aegyptius). Grupo de Estudo da Febre Purpúrica Brasileira].[巴西紫癜热，埃及嗜血杆菌（流感嗜血杆菌生物群埃及亚种）动物模型中的毒力。巴西紫癜热研究小组]
Rev Inst Med Trop Sao Paulo. 1993 May-Jun;35(3):259-69.
8
Lethal Haemophilus influenzae type b infection in mice.小鼠中的致死性B型流感嗜血杆菌感染。
Infection. 1982 Sep-Oct;10(5):261-6. doi: 10.1007/BF01640870.
9
Haemophilus influenzae disease and immunization in developing countries.发展中国家的流感嗜血杆菌疾病与免疫接种
Rev Infect Dis. 1991 May-Jun;13 Suppl 6:S542-54. doi: 10.1093/clinids/13.supplement_6.s542.
10
Comparison of radiometric and conventional culture systems in detecting Haemophilus influenzae type b bacteremia in rats.放射性测量法与传统培养系统在检测大鼠B型流感嗜血杆菌菌血症中的比较
J Clin Microbiol. 1985 Aug;22(2):225-8. doi: 10.1128/jcm.22.2.225-228.1985.

引用本文的文献

1
Chromosome replication as a measure of bacterial growth rate during Escherichia coli infection in the mouse peritonitis model.在小鼠腹膜炎模型中，用染色体复制作为衡量大肠杆菌感染期间细菌生长速度的指标。
Sci Rep. 2018 Oct 8;8(1):14961. doi: 10.1038/s41598-018-33264-7.
2
Influence of growth rate on susceptibility to antimicrobial agents: modification of the cell envelope and batch and continuous culture studies.生长速率对抗菌剂敏感性的影响：细胞包膜的修饰以及分批培养和连续培养研究
Antimicrob Agents Chemother. 1990 Sep;34(9):1623-8. doi: 10.1128/AAC.34.9.1623.
3
Characterization of a mutant of Haemophilus influenzae type b lacking the P2 major outer membrane protein.b型流感嗜血杆菌缺乏P2主要外膜蛋白的突变体的特性分析
Infect Immun. 1990 Oct;58(10):3312-8. doi: 10.1128/iai.58.10.3312-3318.1990.

本文引用的文献

1
Cellular resistance to infection.细胞抗感染能力。
J Exp Med. 1962 Sep 1;116(3):381-406. doi: 10.1084/jem.116.3.381.
2
The growth of micro-organisms in vivo with particular reference to the relation between dose and latent period.微生物在体内的生长，特别涉及剂量与潜伏期之间的关系。
J Hyg (Lond). 1958 Sep;56(3):323-46. doi: 10.1017/s0022172400037827.
3
Virulence in leptospira. II. The growth in vivo of virulent Leptospira icterohaemorrhagiae.钩端螺旋体的毒力。II. 致病性出血性黄疸钩端螺旋体在体内的生长
Br J Exp Pathol. 1957 Feb;38(1):8-14.
4
Dynamics of bacterial infections in mice under conditions known to alter survival time.在已知会改变存活时间的条件下小鼠细菌感染的动态变化
J Infect Dis. 1956 Mar-Apr;98(2):198-207. doi: 10.1093/infdis/98.2.198.
5
Haemophilus influenzae b infection in rats: effect of splenectomy on bloodstream and meningeal invasion after intravenous and intranasal inoculations.大鼠B型流感嗜血杆菌感染：脾切除对静脉内和鼻内接种后血流及脑膜侵袭的影响
Infect Immun. 1980 Mar;27(3):872-5. doi: 10.1128/iai.27.3.872-875.1980.
6
Surface determinants of Haemophilus influenzae pathogenicity: comparative virulence of capsular transformants in normal and complement-depleted rats.流感嗜血杆菌致病性的表面决定因素：正常和补体缺陷大鼠中荚膜转化体的比较毒力
J Infect Dis. 1983 Sep;148(3):385-94. doi: 10.1093/infdis/148.3.385.
7
Pathogenesis of bloodstream invasion with Haemophilus influenzae type b.b型流感嗜血杆菌血流侵袭的发病机制。
Infect Immun. 1983 Jul;41(1):280-4. doi: 10.1128/iai.41.1.280-284.1983.
8
The third component of the guinea pig complement system. II. Kinetic study of the reaction of EAC'4,2a with guinea pig C'3. Enzymatic nature of C'3 comsumption, multiphasic character of fixation, and hemolytic titration of C'3.豚鼠补体系统的第三个成分。II. EAC'4,2a与豚鼠C'3反应的动力学研究。C'3消耗的酶学性质、结合的多相特征以及C'3的溶血滴定
Biochemistry. 1968 Aug;7(8):2997-3002. doi: 10.1021/bi00848a041.
9
Enhancement of bacterial infection by ferric iron: kinetics, mechanisms, and surgical significance.铁离子增强细菌感染：动力学、机制及外科意义
Surgery. 1971 Jul;70(1):71-7.
10
Microbial growth rates in nature.自然界中的微生物生长速率。
Bacteriol Rev. 1971 Mar;35(1):39-58. doi: 10.1128/br.35.1.39-58.1971.

b型流感嗜血杆菌体内和体外增殖率的比较

Comparison of in vivo and in vitro multiplication rates of Haemophilus influenzae type b.

作者信息

Rubin L G

出版信息

Infect Immun. 1986 Jun;52(3):911-3. doi: 10.1128/iai.52.3.911-913.1986.

DOI:10.1128/iai.52.3.911-913.1986
PMID:3486830
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC260949/
Abstract

A model of invasive Haemophilus influenzae type b disease in rats was used to compare the net in vivo and in vitro multiplication rates of this bacterium. In both the blood of rats and in vitro cultures (fresh rat blood or enriched broth) there was an exponential increase in the number of CFU per milliliter with calculated net mean generation times as follows: sham-operated rats, 82 +/- 39 min (n = 5); asplenic rats, 34 +/- 5 min (n = 13); broth, 26 +/- 4 min (n = 12); rat blood, 24 +/- 1 min (n = 14). Thus, in vivo multiplication of H. influenzae type b can be extremely efficient.

摘要

利用大鼠侵袭性b型流感嗜血杆菌疾病模型比较该细菌在体内和体外的净增殖率。在大鼠血液和体外培养物（新鲜大鼠血液或富集肉汤）中，每毫升菌落形成单位（CFU）数量呈指数增长，计算得出的净平均代时如下：假手术大鼠，82±39分钟（n = 5）；无脾大鼠，34±5分钟（n = 13）；肉汤，26±4分钟（n = 12）；大鼠血液，24±1分钟（n = 14）。因此，b型流感嗜血杆菌在体内的增殖效率可能极高。