b型流感嗜血杆菌体内和体外增殖率的比较
Comparison of in vivo and in vitro multiplication rates of Haemophilus influenzae type b.
作者信息
Rubin L G
出版信息
Infect Immun. 1986 Jun;52(3):911-3. doi: 10.1128/iai.52.3.911-913.1986.
Abstract
A model of invasive Haemophilus influenzae type b disease in rats was used to compare the net in vivo and in vitro multiplication rates of this bacterium. In both the blood of rats and in vitro cultures (fresh rat blood or enriched broth) there was an exponential increase in the number of CFU per milliliter with calculated net mean generation times as follows: sham-operated rats, 82 +/- 39 min (n = 5); asplenic rats, 34 +/- 5 min (n = 13); broth, 26 +/- 4 min (n = 12); rat blood, 24 +/- 1 min (n = 14). Thus, in vivo multiplication of H. influenzae type b can be extremely efficient.
摘要
利用大鼠侵袭性b型流感嗜血杆菌疾病模型比较该细菌在体内和体外的净增殖率。在大鼠血液和体外培养物（新鲜大鼠血液或富集肉汤）中，每毫升菌落形成单位（CFU）数量呈指数增长，计算得出的净平均代时如下：假手术大鼠，82±39分钟（n = 5）；无脾大鼠，34±5分钟（n = 13）；肉汤，26±4分钟（n = 12）；大鼠血液，24±1分钟（n = 14）。因此，b型流感嗜血杆菌在体内的增殖效率可能极高。
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