Azzam Ahmed Y, Ghozy Sherief, Azab Mohammed A
October 6 University Faculty of Medicine, Giza, Egypt.
Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Interdiscip Neurosurg. 2022 Mar;27:101441. doi: 10.1016/j.inat.2021.101441. Epub 2021 Nov 28.
A novel coronavirus reportedly called 2019-nCoV started to spread around the world at the end of 2019. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was later renamed after links with SARS were observed. Multiple studies have reported possible connections between the COVID-19 virus and neurodegenerative diseases, including Parkinson's disease. Theories support that vitamin D deficiency plays a part in the pathogenicity of Parkinson's disease or the credibility of the associated dopamine system. Administration of vitamin D3 was shown to significantly enhance the motor and non-motor manifestations of Parkinson's disease and enhance the quality of life. Also, multiple recent reviews have shown specific ways in which vitamin D reduces the risk of pathogenic infections. Recent studies supported the potential role of vitamin D in reducing the risk of COVID-19 infections and mortality. On the immunological level, immune response regulation remains one of the well-recognized actions of vitamin D. Vitamin D deficiency has been linked to complications in patients with SARS-CoV-2 infection and Parkinson's disease. Whereas more studies are required, Vitamin D supplementation with a moderate and well-calculated dosage of vitamin D3 in patients with Parkinson's disease can help minimize the risk and burden of COVID-19 complications.
据报道，一种名为2019-nCoV的新型冠状病毒于2019年底开始在全球传播。后来，在观察到与严重急性呼吸综合征冠状病毒（SARS-CoV）的关联后，将其重新命名为严重急性呼吸综合征冠状病毒2（SARS-CoV-2）。多项研究报告了2019冠状病毒病（COVID-19）病毒与神经退行性疾病（包括帕金森病）之间可能存在的联系。理论支持维生素D缺乏在帕金森病的致病性或相关多巴胺系统的可信度中起作用。研究表明，给予维生素D3可显著改善帕金森病的运动和非运动症状，并提高生活质量。此外，最近的多项综述显示了维生素D降低致病性感染风险的具体方式。最近的研究支持了维生素D在降低COVID-19感染风险和死亡率方面的潜在作用。在免疫层面，免疫反应调节仍然是维生素D广为人知的作用之一。维生素D缺乏与SARS-CoV-2感染患者和帕金森病患者的并发症有关。虽然还需要更多的研究，但在帕金森病患者中补充适量且计算精确的维生素D3有助于将COVID-19并发症的风险和负担降至最低。
