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制作带锐边的 3D 微颗粒 PDMS 微流控通道的折叠结构

Fabrication of sharp-edged 3D microparticles folded PDMS microfluidic channels.

机构信息

State Key Laboratory of Tribology, Tsinghua University, Beijing 100084, China.

School of Mechanical Engineering, University of Science and Technology Beijing, Beijing 100083, China.

出版信息

Lab Chip. 2021 Dec 21;22(1):148-155. doi: 10.1039/d1lc00807b.

DOI:10.1039/d1lc00807b
PMID:34870665
Abstract

3D microparticles have promising applications in self-assembly, biomedical engineering, mechanical engineering, The shape of microparticles plays a significant role in their functionalities. Although numerous investigations have been conducted to tailor the shape of microparticles, the diversity is still limited, and it remains a challenge to fabricate 3D microparticles with sharp edges. Here, we present a facile approach that combines a folded PDMS channel and orthogonal projection lithography for shaping sharp-edged 3D microparticles. By adjusting the number and the length of channel sides, both regular and irregular polyhedral cross-sections of the folded channel can be obtained. UV light with diverse patterns is applied vertically as the second shape controlling factor. A variety of 3D microparticles are obtained with sharp edges, which are potential templates for micromachining tools and abrasives. Some sharp-edged microparticles are assembled into 2D and 3D mesoscale structures, which demonstrates their prospective applications in self-assembly, tissue engineering,

摘要

3D 微球在自组装、生物医学工程、机械工程等领域具有广阔的应用前景。微球的形状在其功能中起着重要作用。尽管已经进行了大量的研究来调整微球的形状,但多样性仍然有限,制造具有锐利边缘的 3D 微球仍然是一个挑战。在这里,我们提出了一种简单的方法,结合折叠 PDMS 通道和正交投影光刻来形成具有锐利边缘的 3D 微球。通过调整通道侧面的数量和长度,可以获得规则和不规则的多面体横截面。具有不同图案的紫外光作为第二个形状控制因素垂直照射。获得了具有锐利边缘的各种 3D 微球,它们是微加工工具和磨料的潜在模板。一些具有锐利边缘的微球被组装成 2D 和 3D 介观结构,这表明它们在自组装、组织工程等领域具有潜在的应用前景。

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