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Toxins (Basel). 2020 Jan 21;12(2):67. doi: 10.3390/toxins12020067.
2
Escherichia coli O80 hybrid pathotype strains producing Shiga toxin and ESBL: molecular characterization and potential therapeutic options.产志贺毒素和 ESBL 的大肠杆菌 O80 混合流行株：分子特征及潜在治疗选择。
J Antimicrob Chemother. 2020 Mar 1;75(3):537-542. doi: 10.1093/jac/dkz484.
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PlasmidFinder and In Silico pMLST: Identification and Typing of Plasmid Replicons in Whole-Genome Sequencing (WGS).质粒查找器和计算机 pMLST：全基因组测序（WGS）中质粒复制子的鉴定和分型。
Methods Mol Biol. 2020;2075:285-294. doi: 10.1007/978-1-4939-9877-7_20.
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Shiga toxin-induced haemolytic uraemic syndrome and the role of antibiotics: a global overview.志贺毒素引起的溶血尿毒综合征和抗生素的作用：全球概述。
J Infect. 2019 Aug;79(2):75-94. doi: 10.1016/j.jinf.2019.05.018. Epub 2019 May 28.
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Azithromycin resistance levels and mechanisms in Escherichia coli.大肠杆菌中阿奇霉素耐药水平和机制。
Sci Rep. 2019 Apr 15;9(1):6089. doi: 10.1038/s41598-019-42423-3.
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2004 年至 2020 年法国产志贺毒素大肠杆菌的阿奇霉素耐药性和（C）-（G）基因的检测。

Azithromycin Resistance in Shiga Toxin-Producing Escherichia coli in France between 2004 and 2020 and Detection of (C)-(G) Genes.

机构信息

Service de Microbiologie, Centre National de Référence Escherichia coli, Hôpital Robert-Debré, Paris, France.

Université de Paris, IAME, INSERM, Paris, France.

出版信息

Antimicrob Agents Chemother. 2022 Feb 15;66(2):e0194921. doi: 10.1128/AAC.01949-21. Epub 2021 Dec 6.

DOI:10.1128/AAC.01949-21
PMID:34871091
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8846429/
Abstract

We described and characterized Shiga-toxin-producing Escherichia coli (STEC) strains with high levels of resistance to azithromycin isolated in France between 2004 and 2020. Nine of 1,715 (0.52%) STEC strains were resistant to azithromycin, with an increase since 2017. One isolate carried a plasmid-borne (C)-(G) gene combination, described here for the first time for E. coli. Azithromycin resistance, although rare, needs consideration, as this treatment may be useful in cases of STEC infection.

摘要

我们描述并鉴定了 2004 年至 2020 年间在法国分离出的具有高水平耐阿奇霉素的产志贺毒素大肠杆菌（STEC）菌株。在 1715 株 STEC 菌株中，有 9 株（0.52%）对阿奇霉素耐药，自 2017 年以来有所增加。一个分离株携带质粒携带的（C）-（G）基因组合，这是首次在大肠杆菌中描述。阿奇霉素耐药虽然罕见，但仍需考虑，因为这种治疗可能对 STEC 感染有用。