Center for Veterinary Medicine, U.S. Food and Drug Administration , Laurel, Maryland, USA.
Division of Foodborne, Waterborne, and Environmental Diseases, Centers for Disease Control and Prevention , Atlanta, Georgia, USA.
Microbiol Spectr. 2024 Jan 11;12(1):e0348523. doi: 10.1128/spectrum.03485-23. Epub 2023 Nov 22.
Macrolides of different ring sizes are critically important antimicrobials for human medicine and veterinary medicine, though the widely used 15-membered ring azithromycin in humans is not approved for use in veterinary medicine. We document here the emergence of azithromycin-resistant among the NARMS culture collections between 2011 and 2021 in food animals and retail meats, some with co-resistance to ceftriaxone or decreased susceptibility to ciprofloxacin. We also provide insights into the underlying genetic mechanisms and genomic contexts, including the first report of a novel combination of azithromycin resistance determinants and the characterization of multidrug-resistant plasmids. Further, we highlight the emergence of a multidrug-resistant Newport clone in food animals (mainly cattle) with both azithromycin resistance and decreased susceptibility to ciprofloxacin. These findings contribute to a better understating of azithromycin resistance mechanisms in and warrant further investigations on the drivers behind the emergence of resistant clones.
大环内酯类药物具有不同的环大小，对人类医学和兽医学至关重要，尽管在人类中广泛使用的 15 元环阿奇霉素尚未被批准用于兽医。我们在此记录了在 2011 年至 2021 年期间，食品动物和零售肉类中的耐阿奇霉素 的出现，其中一些对头孢曲松具有共同耐药性或对环丙沙星的敏感性降低。我们还提供了对潜在遗传机制和基因组背景的深入了解，包括对阿奇霉素耐药决定因素的新型组合的首次报道，以及对多药耐药质粒的特征描述。此外，我们还强调了在食品动物（主要是牛）中出现的具有阿奇霉素耐药性和对环丙沙星敏感性降低的多药耐药性 纽波特克隆。这些发现有助于更好地理解 中的阿奇霉素耐药机制，并需要进一步研究耐药克隆出现的驱动因素。
