PON1（L55M 和 Q192R）基因多态性与接触农药的北印度女性复发性妊娠丢失的关系。
Association Between PON1 (L55M and Q192R) Genetic Polymorphism and Recurrent Pregnancy Loss in North Indian Women Exposed to Pesticides.
机构信息
Department of Obstetrics and Gynecology, King George's Medical University, Lucknow, Uttar Pradesh, India.
Department of Biochemistry, KGMU, Lucknow, Uttar Pradesh, India.
出版信息
Rev Bras Ginecol Obstet. 2021 Nov;43(11):805-810. doi: 10.1055/s-0041-1736342. Epub 2021 Dec 6.
OBJECTIVE
The aim of the present study was to examine the relation between the PON1 polymorphisms and recurrent pregnancy loss (RPL).
METHODS
In a cross-sectional study, blood samples were collected from 100 females. DNA was extracted and PON1 genotypes were determined by polymerase chain reaction (PCR) amplification.
RESULTS
Regarding PON1 L55M, the mutated allele (M) frequency was found in 70.5% in RPL and in 53.5% in controls; the M allele was significantly associated with an increased risk of RPL (adjusted odds ratio [OR= 2.07; 95% confidence interval [CI]; < 0.001). However, regarding PON1 Q192R, the R mutated allele frequency was found in 28.5% in RPL and in 33% in controls. The R allele did not show any risk for RPL (OR 0.81; 95%CI; = 0.329).
CONCLUSION
The present study suggests that there is an effect of genetic polymorphism on RPL and provides additional evidence that combines with the growing information about the ways in which certain PON1 genotypes can affect the development of the fetus in the uterus.
目的
本研究旨在探讨 PON1 多态性与复发性妊娠丢失（RPL）之间的关系。
方法
在一项横断面研究中，采集了 100 名女性的血样。提取 DNA 后，通过聚合酶链反应（PCR）扩增确定 PON1 基因型。
结果
关于 PON1 L55M，RPL 组中突变等位基因（M）频率为 70.5%，对照组中为 53.5%；M 等位基因与 RPL 风险增加显著相关（调整后的优势比[OR]为 2.07；95%置信区间[CI]； < 0.001）。然而，关于 PON1 Q192R，RPL 组中突变等位基因 R 频率为 28.5%，对照组中为 33%。R 等位基因对 RPL 无风险（OR 0.81；95%CI； = 0.329）。
结论
本研究提示遗传多态性对 RPL 有影响，并提供了额外的证据，结合了有关某些 PON1 基因型如何影响子宫内胎儿发育的信息。
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