甲氧苄啶-磺胺甲恶唑预防对卡氏肺孢子虫的作用有限。
Limited effect of trimethoprim-sulfamethoxazole prophylaxis on Pneumocystis carinii.
作者信息
Hughes W T
出版信息
Antimicrob Agents Chemother. 1979 Sep;16(3):333-5. doi: 10.1128/AAC.16.3.333.
Abstract
Trimethoprim-sulfamethoxazole has been proven effective in the treatment and prevention of Pneumocystis carinii pneumonitis in lower animals and humans. How effective the drug combination is in eradicating P. carinii from the host is not known. The immunosuppressed rat model was used to determine whether or not trimethoprim-sulfamethoxazole effectively eradicated the organism. Animals treated with trimethoprim-sulfamethoxazole for as long as 6 weeks were then placed in individual isolator cages, immunosuppressed with prednisone for 12 weeks, and sacrificed. P. carinii was found in the lungs of at least 90% of the drug-treated as well as untreated control groups. The data indicate that trimethoprim-sulfamethoxazole has a limited rather than a lethal effect on P. carinii and that protection is afforded only during the period of trimethoprim-sulfamethoxazole administration.
摘要
甲氧苄啶-磺胺甲恶唑已被证明在治疗和预防低等动物及人类的卡氏肺孢子虫肺炎方面有效。该药物组合在从宿主体内根除卡氏肺孢子虫方面的效果尚不清楚。使用免疫抑制大鼠模型来确定甲氧苄啶-磺胺甲恶唑是否能有效根除该病原体。用甲氧苄啶-磺胺甲恶唑治疗长达6周的动物随后被置于单独的隔离笼中，用泼尼松免疫抑制12周，然后处死。在至少90%的药物治疗组和未治疗的对照组的肺中都发现了卡氏肺孢子虫。数据表明，甲氧苄啶-磺胺甲恶唑对卡氏肺孢子虫的作用有限而非致命，并且仅在给予甲氧苄啶-磺胺甲恶唑期间提供保护。
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本文引用的文献
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