用4,4'-磺酰双甲酰苯胺成功治疗和预防小鼠卡氏肺孢子虫肺炎。
Successful treatment and prevention of murine Pneumocystis carinii pneumonitis with 4,4'-sulfonylbisformanilide.
作者信息
Hughes W T, Smith B L, Jacobus D P
出版信息
Antimicrob Agents Chemother. 1986 Mar;29(3):509-10. doi: 10.1128/AAC.29.3.509.
Abstract
Pneumocystis carinii pneumonitis was prevented in 0, 50, 100, and 100% of immunosuppressed rats given doses of 0.5, 5.0, 25.0, and 125.0 mg/kg (body weight) per day, respectively, of 4,4'-sulfonylbisformanilide (DFD). Therapeutic efficacy was demonstrated with DFD at 25.0 mg/kg per day, and when this dose was combined with trimethoprim, the combination was as effective as trimethoprim-sulfamethoxazole, which has been proven to be effective in the treatment of murine and human P. carinii pneumonitis.
摘要
分别给予免疫抑制大鼠每日0.5、5.0、25.0和125.0毫克/千克（体重）剂量的4,4'-磺酰双甲酰苯胺（DFD），卡氏肺孢子虫肺炎在接受这些剂量的大鼠中的预防率分别为0%、50%、100%和100%。每日25.0毫克/千克剂量的DFD显示出治疗效果，当该剂量与甲氧苄啶联合使用时，联合用药与甲氧苄啶-磺胺甲恶唑的效果相同，后者已被证明对治疗小鼠和人类卡氏肺孢子虫肺炎有效。
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