Azeez Juberiya M, Susmi Thachapillil Ramakrishnan, Remadevi Viji, Ravindran Vini, Sasikumar Sujatha Anjana, Ayswarya Raveendran Nair Sobha, Sreeja Sreeharshan
Cancer Research Program, Rajiv Gandhi Centre for Biotechnology Thiruvananthapuram, India.
Am J Cancer Res. 2021 Nov 15;11(11):5214-5232. eCollection 2021.
Progesterone, the ovarian steroid hormone, regulates a plentitude of biological processes in tissues ranging from the brain to bones. Recognizing the role of progesterone and its receptors in physiological processes and maladies can prevent and treat various diseases. Apart from its physiological functions, its role in developing diseases, especially breast cancer, is a recent topic of deliberation. There exists conflicting experimental and epidemiological evidence linking progesterone to breast cancer. This review tries to describe the physiological functions of progesterone and its receptors, genomic and non-genomic signaling, splice variants, and a different aspect of progesterone signaling. Furthermore, we seek to address or attempt to discuss the following pertinent questions on steroid hormone signaling; How does progesterone influence breast cancer progression? How does it change the molecular pathways in breast cancer with different receptor statuses, the specific role of each isoform, and how does the ER/and PR ratio affect progesterone signaling?
孕酮，一种卵巢甾体激素，可调节从大脑到骨骼等多种组织中的大量生物过程。认识到孕酮及其受体在生理过程和疾病中的作用有助于预防和治疗各种疾病。除了其生理功能外，它在疾病尤其是乳腺癌发生过程中的作用是近期的一个讨论话题。关于孕酮与乳腺癌之间的联系，存在相互矛盾的实验和流行病学证据。本综述试图描述孕酮及其受体的生理功能、基因组和非基因组信号传导、剪接变体以及孕酮信号传导的不同方面。此外，我们试图回答或讨论以下关于甾体激素信号传导的相关问题：孕酮如何影响乳腺癌进展？它如何改变不同受体状态的乳腺癌中的分子途径、每种异构体的具体作用以及雌激素受体/孕激素受体比例如何影响孕酮信号传导？
