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预测IB-IIA期宫颈癌患者术后生存率的列线图模型

Nomogram model for predicting postoperative survival of patients with stage IB-IIA cervical cancer.

作者信息

Yang Huan-Song, Li Bin, Liu Shuang-Huan, Ao Miao

机构信息

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021, China.

出版信息

Am J Cancer Res. 2021 Nov 15;11(11):5559-5570. eCollection 2021.

Abstract

To establish a prediction model based on clinical and pathological information for the long-term survival of patients with cervical cancer, we retrospectively analyzed the clinical data of patients pathologically diagnosed with stage IB-IIA cervical cancer between July 2007 and September 2017 in the Chinese Academy of Medical Sciences Cancer Hospital. Factors affecting the overall survival of the patients were analyzed using a Cox model, and a cervical cancer patient prediction nomogram model was established. A total of 2,319 patients were included in the study. According to the multivariate Cox regression analysis, number of complications, surgical methods, neoadjuvant treatment, lymph node metastasis, postoperative treatment, lymphovascular space invasion (LVSI), and other independent factors affecting prognosis were included to establish a nomogram. The nomogram consistency index in the training and validation cohorts was 0.691 and 0.615, respectively. The study established a highly accurate predictive model for the postoperative survival of cervical cancer patients.

摘要

为基于临床和病理信息建立宫颈癌患者长期生存的预测模型,我们回顾性分析了2007年7月至2017年9月在中国医学科学院肿瘤医院经病理诊断为IB-IIA期宫颈癌患者的临床资料。使用Cox模型分析影响患者总生存的因素,并建立宫颈癌患者预测列线图模型。本研究共纳入2319例患者。根据多因素Cox回归分析,纳入并发症数量、手术方式、新辅助治疗、淋巴结转移、术后治疗、脉管间隙浸润(LVSI)等影响预后的独立因素来建立列线图。训练队列和验证队列中的列线图一致性指数分别为0.691和0.615。本研究建立了一个预测宫颈癌患者术后生存的高度准确的预测模型。

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