Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai, China.
Department of General Medicine, The First Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai, China.
Allergol Immunopathol (Madr). 2022 Jan 1;50(1):9-16. doi: 10.15586/aei.v50i1.490. eCollection 2022.
Bronchial asthma is a common chronic airway disease, and long-term management of asthma is the focus and challenge of clinical treatment. Glucocorticoids are often used as the first choice for the treatment of asthma. However, the occurrence of hormone dependence, hormone resistance, and local and systemic adverse reactions caused by hormone application also creates problems for the treatment of asthma. Finding new, safe, and effective therapeutic drugs is an important research direction at present. Icariin is an effective ingredient of the traditional Chinese medicine, Epimedium. It has various biological attributes such as anti-inflammatory and antioxidative activities, and immune regulation. It has high safety and a wide range of clinical applications. Icariin has the characteristics of multitargeted intervention in the treatment of asthma. Here, we review the specific mechanisms of icariin in treating asthma, and icariin is considered a novel therapy in controlling asthma; however, the mechanism is still worth further investigation.
支气管哮喘是一种常见的慢性气道疾病，哮喘的长期管理是临床治疗的重点和挑战。糖皮质激素通常被用作哮喘治疗的首选药物。然而，激素应用引起的激素依赖性、激素抵抗以及局部和全身不良反应也给哮喘的治疗带来了问题。寻找新的、安全有效的治疗药物是目前的一个重要研究方向。淫羊藿苷是中药淫羊藿的有效成分，具有抗炎、抗氧化和免疫调节等多种生物学特性，安全性高，临床应用广泛。淫羊藿苷在治疗哮喘方面具有多靶点干预的特点。在这里，我们综述了淫羊藿苷治疗哮喘的具体机制，认为淫羊藿苷是控制哮喘的一种新型治疗方法，但机制仍值得进一步研究。
