Department of Chemistry, Laboratory of Catalysis and Organic Synthesis, Indian Institute of Technology Roorkee, Roorkee-247667, Uttarakhand, India.
Chem Commun (Camb). 2021 Dec 21;58(1):10-28. doi: 10.1039/d1cc05899a.
-Heteroarenes are widely used for numerous medicinal applications, lifesaving drugs and show utmost importance as intermediates in chemical synthesis. This feature article highlights the recent advances, from 2015 to August 2021, on sp and sp C-H bond functionalization reactions of various -heteroarenes catalyzed by non-precious transition metals (Mn, Co, Fe, Ni, ). The salient features of the report are: (i) the development of newer catalysis for Csp-H activation of -heteroarenes and categorized into alkylation, alkenylation, borylation, cyanation, and annulation reactions, (ii) recent advances on Csp-H bond functionalization of -heteroarenes considering newer approaches for alkylation as well as alkenylation processes, and (iii) synthetic applications and practical utility of the catalytic protocols utilized for late-stage drug development; (iv) scope for the development of newer catalytic protocols along with mechanistic studies and detail mechanistic findings of various important processes.
杂芳烃广泛应用于众多医药用途，是救生药物，并且在化学合成中作为中间体表现出极其重要的作用。本文重点介绍了 2015 年至 2021 年 8 月间，非贵金属（Mn、Co、Fe、Ni、）催化的各种杂芳烃 sp 和 sp2 C-H 键功能化反应的最新进展。报告的突出特点是：（i）开发了用于杂芳烃 Csp-H 活化的新型催化，分为烷基化、烯基化、硼化、氰化和环化反应，（ii）杂芳烃 Csp-H 键功能化的最新进展，考虑了烷基化和烯基化过程的新方法，以及（iii）用于药物后期开发的催化方案的合成应用和实际效用；（iv）新型催化方案的发展前景以及各种重要过程的详细机理研究和机理发现。
