2 型糖尿病很容易因高血糖和胰岛素抵抗发展为阿尔茨海默病。
Type 2 Diabetes Mellitus Easily Develops into Alzheimer's Disease via Hyperglycemia and Insulin Resistance.
机构信息
Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China and Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
出版信息
Curr Med Sci. 2021 Dec;41(6):1165-1171. doi: 10.1007/s11596-021-2467-2. Epub 2021 Dec 6.
With the acceleration of population aging, the incidence of type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) is progressively increasing due to the age-relatedness of these two diseases. The association between T2DM and AD-like dementia is receiving much attention, and T2DM is reported to be a significant risk factor for AD. The aims of this review were to reveal the brain changes caused by T2DM as well as to explore the roles of hyperglycemia and insulin resistance in the development of AD.
随着人口老龄化的加速，由于这两种疾病与年龄有关，2 型糖尿病（T2DM）和阿尔茨海默病（AD）的发病率也在逐渐增加。T2DM 与 AD 样痴呆之间的关联受到了广泛关注，并且 T2DM 被报道是 AD 的一个重要危险因素。本综述的目的是揭示 T2DM 引起的大脑变化，并探讨高血糖和胰岛素抵抗在 AD 发展中的作用。
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