脑类器官的活动诱导不稳定性。
Activity-induced instabilities of brain organoids.
机构信息
Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Rd, CB2 1EW, Cambridge, UK.
Department of Applied physics, Eindhoven University of Technology, Eindhoven, The Netherlands.
出版信息
Eur Phys J E Soft Matter. 2021 Dec 7;44(12):147. doi: 10.1140/epje/s10189-021-00149-z.
We present an analytical and numerical investigation of the activity-induced hydrodynamic instabilities in model brain organoids. While several mechanisms have been introduced to explain the experimental observation of surface instabilities in brain organoids, the role of activity has been largely overlooked. Our results show that the active stress generated by the cells can be a, previously overlooked, contributor to the emergence of surface deformations in brain organoids.
我们对模型脑类器官中的活性诱导的流体动力不稳定性进行了分析和数值研究。虽然已经提出了几种机制来解释脑类器官中表面不稳定性的实验观察，但活性的作用在很大程度上被忽视了。我们的结果表明，细胞产生的主动应力可能是脑类器官表面变形出现的一个以前被忽视的因素。
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