Lee Seung Eun, Park Su-Kyung, Park Ye-Seul, Kim Kyoung-Ah, Choi Han Seok, Oh Sang Woo
Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Korea.
Department of Family Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Korea.
J Obes Metab Syndr. 2021 Dec 30;30(4):345-353. doi: 10.7570/jomes21047.
The increasing prevalence of type 2 diabetes mellitus (T2DM) has led to a significant health burden. Technological advancements have highlighted the benefits of digital therapeutics for chronic diseases. In this study, we aimed to investigate the effects of a mobile application on weight reduction in patients with T2DM.
A total of 48 patients with T2DM was included in this single-center, randomized, controlled trial. In addition to conventional treatment, participants in the intervention group used a mobile application-based self-management system for diet, exercise, and medication adherence. The primary outcome of this study was weight change after 3 months of intervention, and secondary outcomes were metabolic parameters.
After 12 weeks, no significant differences in body weight change were observed between the intervention and control groups (=0.229). However, a significant difference was found in waist circumference (WC) between the two groups, wherein the control group showed an increase in WC (from 95.00±8.89 cm to 95.76±9.72 cm), while the intervention group showed a reduction (from 91.93±6.25 cm to 90.75±6.01 cm) with a significant time by group interaction (=0.016). Additionally, participants with good compliance exhibited a more evident reduction in WC (=0.037). However, no significant differences were found in other metabolic parameters between the two groups.
Lifestyle modification using short-term mobile applications effectively reduced WC, especially in patients with good adherence to the application. However, weight reduction was not achieved.
2型糖尿病（T2DM）患病率的不断上升导致了沉重的健康负担。技术进步凸显了数字疗法对慢性病的益处。在本研究中，我们旨在调查一款移动应用程序对T2DM患者体重减轻的影响。
本单中心、随机、对照试验共纳入48例T2DM患者。除常规治疗外，干预组参与者使用基于移动应用程序的饮食、运动和药物依从性自我管理系统。本研究的主要结局是干预3个月后的体重变化，次要结局是代谢参数。
12周后，干预组和对照组之间的体重变化无显著差异（=0.229）。然而，两组之间的腰围（WC）存在显著差异，其中对照组的WC增加（从95.00±8.89厘米增加到95.76±9.72厘米），而干预组则减少（从91.93±6.25厘米减少到90.75±6.01厘米），且组间交互作用有显著时间差异（=0.016）。此外，依从性良好的参与者WC降低更为明显（=0.037）。然而，两组之间的其他代谢参数无显著差异。
使用短期移动应用程序进行生活方式改变可有效降低WC，尤其是在对该应用程序依从性良好的患者中。然而，并未实现体重减轻。
