Fortin A, Rabasa-Lhoret R, Lemieux S, Labonté M-E, Gingras V
Institut de Recherches Cliniques de Montréal, Montreal, Quebec, Canada; Department of nutrition, Université de Montréal, Montreal, Quebec, Canada.
Institut de Recherches Cliniques de Montréal, Montreal, Quebec, Canada; Department of nutrition, Université de Montréal, Montreal, Quebec, Canada.
Nutr Metab Cardiovasc Dis. 2018 Dec;28(12):1275-1284. doi: 10.1016/j.numecd.2018.08.005. Epub 2018 Aug 30.
The metabolic syndrome (MS) is an emerging complication in patients with type 1 diabetes (T1D), with no preventive or therapeutic treatment reported yet. We wanted to compare the impact of two 6-month nutritional interventions, based on a Mediterranean (MED) or a low-fat diet, on waist circumference, anthropometric and metabolic outcomes in patients with both T1D and the MS.
Participants were randomized into 2 intervention groups: 1) MED-diet or 2) low-fat diet. The 6-month study included 9 teaching sessions with a registered dietitian. Anthropometric (primary outcome: waist circumference), metabolic and nutritional assessments were performed at inclusion, 3 and 6-month. We used mixed effects models to assess the effects of both interventions. 28 participants were included (50.9 ± 10.3 years old) with a mean BMI of 30.7 ± 3.3 kg/m and a waist circumference of 105.5 ± 8.9 cm at inclusion. A trend towards a greater reduction of dietary fat intakes in the low-fat diet group was observed (P-interaction = 0.09). Waist circumference was reduced at 6-month in both groups (-3.5 cm low-fat; -1.5 cm MED-diet) with no significant difference between groups (P-interaction = 0.43). Body mass index also significantly decreased in both groups (-0.7 kg/m low-fat; -1.1 kg/m MED-diet; P-interaction = 0.56). No significant differences between groups were observed for other metabolic parameters.
This study suggests that a 6-month non-restrictive dietary intervention in patients with T1D and MS could contribute to weight management, without significant differences between interventions for anthropometric and metabolic parameters. Further studies should investigate the long-term benefits of these diets.
NCT02821585 (https://clinicaltrials.gov/).
代谢综合征（MS）是1型糖尿病（T1D）患者中一种新出现的并发症，目前尚无预防性或治疗性措施的报道。我们希望比较两种为期6个月的营养干预措施，即地中海饮食（MED）或低脂饮食，对同时患有T1D和MS的患者腰围、人体测量及代谢指标的影响。
参与者被随机分为2个干预组：1）地中海饮食组；2）低脂饮食组。为期6个月的研究包括与注册营养师进行9次教学课程。在入组时、3个月和6个月时进行人体测量（主要结局指标：腰围）、代谢和营养评估。我们使用混合效应模型评估两种干预措施的效果。共纳入28名参与者（年龄50.9±10.3岁），入组时平均体重指数为30.7±3.3kg/m²，腰围为105.5±8.9cm。观察到低脂饮食组膳食脂肪摄入量有更大幅度降低的趋势（交互作用P值=0.09）。两组在6个月时腰围均有所降低（低脂组降低3.5cm；地中海饮食组降低1.5cm），组间差异无统计学意义（交互作用P值=0.43）。两组体重指数也均显著降低（低脂组降低0.7kg/m²；地中海饮食组降低1.1kg/m²；交互作用P值=0.56）。其他代谢参数组间差异无统计学意义。
本研究表明，对患有T1D和MS的患者进行为期6个月的非限制性饮食干预有助于体重管理，在人体测量和代谢参数的干预效果上无显著差异。进一步研究应探讨这些饮食的长期益处。
NCT02821585（https://clinicaltrials.gov/）
