Department of Ambulatory Oncology Care Unit, Centre Hospitalier Universitaire de Reims, Rue du general Koenig, Reims, France.
University Reims Champagne-Ardenne (URCA), Reims, France.
BMC Surg. 2021 Dec 7;21(1):413. doi: 10.1186/s12893-021-01409-7.
This study evaluated the impact of time to surgery (TTS) on overall survival (OS), disease free survival (DFS) and postoperative complication rate in patients with upfront resected pancreatic adenocarcinoma (PA).
We retrospectively included patients who underwent upfront surgery for PA between January 1, 2004 and December 31, 2014 from four French centers. TTS was defined as the number of days between the date of the first consultation in specialist care and the date of surgery. DFS for a 14-day TTS was the primary endpoint. We also analyzed survival depending on different delay cut-offs (7, 14, 28, 60 and 75 days).
A total of 168 patients were included. 59 patients (35%) underwent an upfront surgery within 14 days. Patients in the higher delay group (> 14 days) had significantly more vein resections and endoscopic biliary drainage. Adjusted OS (p = 0.44), DFS (p = 0.99), fistulas (p = 0.41), hemorrhage (p = 0.59) and severe post-operative complications (p = 0.82) were not different according to TTS (> 14 days). Other delay cut-offs had no impact on OS or DFS.
TTS seems to have no impact on OS, DFS and 90-day postoperative morbidity.
本研究评估了手术时间（TTS）对接受初始切除的胰腺腺癌（PA）患者总生存（OS）、无病生存（DFS）和术后并发症发生率的影响。
我们回顾性纳入了 2004 年 1 月 1 日至 2014 年 12 月 31 日期间来自法国四个中心的接受初始手术治疗的 PA 患者。TTS 定义为从首次在专科就诊到手术的天数。TTS 为 14 天的 DFS 为主要终点。我们还根据不同的延迟截止时间（7、14、28、60 和 75 天）分析了生存情况。
共纳入 168 例患者。59 例（35%）患者在 14 天内接受了初始手术。延迟时间较长（>14 天）的患者静脉切除和内镜胆道引流明显更多。调整后的 OS（p=0.44）、DFS（p=0.99）、瘘管（p=0.41）、出血（p=0.59）和严重术后并发症（p=0.82）与 TTS（>14 天）无关。其他延迟截止时间对 OS 或 DFS 没有影响。
TTS 似乎对 OS、DFS 和 90 天术后发病率没有影响。
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