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基于卷积神经网络和逐层相关性传播的冻结步态前特征运动学建模与识别。

Modelling and identification of characteristic kinematic features preceding freezing of gait with convolutional neural networks and layer-wise relevance propagation.

机构信息

Intelligent Mobile Platform Research Group, Department of Mechanical Engineering, KU Leuven, Andreas Vesaliusstraat 13, 3000, Leuven, Belgium.

eMedia Research Lab/STADIUS, Department of Electrical Engineering (ESAT), KU Leuven, Andreas Vesaliusstraat 13, 3000, Leuven, Belgium.

出版信息

BMC Med Inform Decis Mak. 2021 Dec 7;21(1):341. doi: 10.1186/s12911-021-01699-0.


DOI:10.1186/s12911-021-01699-0
PMID:34876110
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8650332/
Abstract

BACKGROUND: Although deep neural networks (DNNs) are showing state of the art performance in clinical gait analysis, they are considered to be black-box algorithms. In other words, there is a lack of direct understanding of a DNN's ability to identify relevant features, hindering clinical acceptance. Interpretability methods have been developed to ameliorate this concern by providing a way to explain DNN predictions. METHODS: This paper proposes the use of an interpretability method to explain DNN decisions for classifying the movement that precedes freezing of gait (FOG), one of the most debilitating symptoms of Parkinson's disease (PD). The proposed two-stage pipeline consists of (1) a convolutional neural network (CNN) to model the reduction of movement present before a FOG episode, and (2) layer-wise relevance propagation (LRP) to visualize the underlying features that the CNN perceives as important to model the pathology. The CNN was trained with the sagittal plane kinematics from a motion capture dataset of fourteen PD patients with FOG. The robustness of the model predictions and learned features was further assessed on fourteen PD patients without FOG and fourteen age-matched healthy controls. RESULTS: The CNN proved highly accurate in modelling the movement that precedes FOG, with 86.8% of the strides being correctly identified. However, the CNN model was unable to model the movement for one of the seven patients that froze during the protocol. The LRP interpretability case study shows that (1) the kinematic features perceived as most relevant by the CNN are the reduced peak knee flexion and the fixed ankle dorsiflexion during the swing phase, (2) very little relevance for FOG is observed in the PD patients without FOG and the healthy control subjects, and (3) the poor predictive performance of one subject is attributed to the patient's unique and severely flexed gait signature. CONCLUSIONS: The proposed pipeline can aid clinicians in explaining DNN decisions in clinical gait analysis and aid machine learning practitioners in assessing the generalization of their models by ensuring that the predictions are based on meaningful kinematic features.

摘要

背景:尽管深度神经网络(DNN)在临床步态分析中表现出了最先进的性能,但它们被认为是黑盒算法。换句话说,人们缺乏对 DNN 识别相关特征的能力的直接理解,这阻碍了其在临床中的接受程度。可解释性方法的发展是为了通过提供一种解释 DNN 预测的方法来缓解这一问题。

方法:本文提出了一种可解释性方法,用于解释 DNN 对分类冻结步态(FOG)前运动的决策,FOG 是帕金森病(PD)最具致残性的症状之一。所提出的两阶段管道包括(1)卷积神经网络(CNN),用于对 FOG 发作前运动的减少进行建模,以及(2)层相关性传播(LRP),用于可视化 CNN 认为对建模病理重要的潜在特征。该 CNN 是用十四名患有 FOG 的 PD 患者的运动捕捉数据集的矢状面运动学进行训练的。还进一步在十四名没有 FOG 的 PD 患者和十四名年龄匹配的健康对照组上评估了模型预测和学习特征的稳健性。

结果:CNN 在对 FOG 前运动进行建模方面表现出了高度的准确性,86.8%的步长被正确识别。然而,CNN 模型无法对协议期间冻结的七名患者中的一名的运动进行建模。LRP 可解释性案例研究表明:(1)CNN 认为最相关的运动学特征是摆动相时减少的膝关节最大屈曲和固定的踝关节背屈,(2)在没有 FOG 的 PD 患者和健康对照组中很少观察到 FOG 的相关性,以及(3)一名患者的预测性能较差归因于该患者独特且严重弯曲的步态特征。

结论:所提出的管道可以帮助临床医生解释临床步态分析中的 DNN 决策,并帮助机器学习从业者通过确保预测基于有意义的运动学特征来评估其模型的泛化能力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e46/8650332/aeca0994c6ea/12911_2021_1699_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e46/8650332/2769710ceb7e/12911_2021_1699_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e46/8650332/aeca0994c6ea/12911_2021_1699_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e46/8650332/2769710ceb7e/12911_2021_1699_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e46/8650332/aeca0994c6ea/12911_2021_1699_Fig2_HTML.jpg

相似文献

[1]
Modelling and identification of characteristic kinematic features preceding freezing of gait with convolutional neural networks and layer-wise relevance propagation.

BMC Med Inform Decis Mak. 2021-12-7

[2]
Automated freezing of gait assessment with marker-based motion capture and multi-stage spatial-temporal graph convolutional neural networks.

J Neuroeng Rehabil. 2022-5-21

[3]
A data-driven approach for detecting gait events during turning in people with Parkinson's disease and freezing of gait.

Gait Posture. 2020-7

[4]
Prediction of Freezing of Gait in Parkinson's Disease from Foot Plantar-Pressure Arrays using a Convolutional Neural Network.

Annu Int Conf IEEE Eng Med Biol Soc. 2020-7

[5]
An Explainable Spatial-Temporal Graphical Convolutional Network to Score Freezing of Gait in Parkinsonian Patients.

Sensors (Basel). 2023-2-4

[6]
AiCarePWP: Deep learning-based novel research for Freezing of Gait forecasting in Parkinson.

Comput Methods Programs Biomed. 2024-9

[7]
Virtual reality doorway and hallway environments alter gait kinematics in people with Parkinson disease and freezing.

Gait Posture. 2022-2

[8]
Real-time detection of freezing of gait in Parkinson's disease using multi-head convolutional neural networks and a single inertial sensor.

Artif Intell Med. 2023-1

[9]
Kin-FOG: Automatic Simulated Freezing of Gait (FOG) Assessment System for Parkinson's Disease.

Sensors (Basel). 2019-5-27

[10]
Effect of freezing of gait and dopaminergic medication in the biomechanics of lower limbs in the gait of patients with Parkinson's disease compared to neurologically healthy.

Neurosci Lett. 2023-5-29

引用本文的文献

[1]
Scoping Review of Machine Learning Techniques in Marker-Based Clinical Gait Analysis.

Bioengineering (Basel). 2025-5-30

[2]
Digital Biomarkers for Parkinson Disease: Bibliometric Analysis and a Scoping Review of Deep Learning for Freezing of Gait.

J Med Internet Res. 2025-5-20

[3]
Insights into Parkinson's Disease-Related Freezing of Gait Detection and Prediction Approaches: A Meta Analysis.

Sensors (Basel). 2024-6-18

[4]
Freezing of gait assessment with inertial measurement units and deep learning: effect of tasks, medication states, and stops.

J Neuroeng Rehabil. 2024-2-13

[5]
The advantages of artificial intelligence-based gait assessment in detecting, predicting, and managing Parkinson's disease.

Front Aging Neurosci. 2023-7-12

[6]
Detection and assessment of Parkinson's disease based on gait analysis: A survey.

Front Aging Neurosci. 2022-8-3

[7]
Automated freezing of gait assessment with marker-based motion capture and multi-stage spatial-temporal graph convolutional neural networks.

J Neuroeng Rehabil. 2022-5-21

本文引用的文献

[1]
Automated freezing of gait assessment with marker-based motion capture and multi-stage spatial-temporal graph convolutional neural networks.

J Neuroeng Rehabil. 2022-5-21

[2]
A data-driven approach for detecting gait events during turning in people with Parkinson's disease and freezing of gait.

Gait Posture. 2020-7

[3]
Deep Learning Approaches for Detecting Freezing of Gait in Parkinson's Disease Patients through On-Body Acceleration Sensors.

Sensors (Basel). 2020-3-29

[4]
Effectiveness of Physiotherapy on Freezing of Gait in Parkinson's Disease: A Systematic Review and Meta-Analyses.

Mov Disord. 2020-4

[5]
Freezing of Gait can persist after an acute levodopa challenge in Parkinson's disease.

NPJ Parkinsons Dis. 2019-11-22

[6]
Toward a Wearable System for Predicting Freezing of Gait in People Affected by Parkinson's Disease.

IEEE J Biomed Health Inform. 2020-9

[7]
Towards Real-Time Prediction of Freezing of Gait in Patients With Parkinson's Disease: Addressing the Class Imbalance Problem.

Sensors (Basel). 2019-9-10

[8]
Layer-Wise Relevance Propagation for Explaining Deep Neural Network Decisions in MRI-Based Alzheimer's Disease Classification.

Front Aging Neurosci. 2019-7-31

[9]
Prediction of Gait Freezing in Parkinsonian Patients: A Binary Classification Augmented With Time Series Prediction.

IEEE Trans Neural Syst Rehabil Eng. 2019-8-6

[10]
Falls in Parkinson's Disease Subtypes: Risk Factors, Locations and Circumstances.

Int J Environ Res Public Health. 2019-6-23

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