Iolascon Giovanni, Giménez Sergio, Mogyorósi Dorottya
Department of Medical and Surgical Specialties and Dentistry, University of Campania "Luigi Vanvitelli", Naples, Italy.
Family Medicine, UGC Limonar, Malaga, Spain.
J Pain Res. 2021 Nov 30;14:3651-3663. doi: 10.2147/JPR.S326101. eCollection 2021.
Aceclofenac is an oral non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. Although there are some differences in the authorized indications between countries, aceclofenac is mainly recommended for the treatment of inflammatory and painful processes, such as low back pain (LBP), scapulohumeral periarthritis, extraarticular rheumatism, odontalgia, and osteoarthritis (OA), rheumatoid arthritis (RA), and ankylosing spondylitis (AS). The analgesic properties and tolerability profile of aceclofenac in musculoskeletal disorders are reviewed, focusing on relevant and recent studies. The efficacy and safety comparison of aceclofenac with other analgesics and anti-inflammatory agents in OA, AS, RA, and LBP is described. Relevant studies were identified following a literature search of PubMed using the terms "aceclofenac" and "clinical trials" published from 1 Jan 1992 to 1 Jan 2020. Aceclofenac is at least as effective as other NSAIDs in reducing pain and/or improving functional capacity in chronic pain conditions (OA, AS, RA, and LBP). It is generally well tolerated and appears to have a more favorable GI profile than other NSAIDs. Thus, current evidence indicates that aceclofenac is a useful option for the management of pain and inflammation across a wide range of painful conditions.
醋氯芬酸是一种具有抗炎和镇痛特性的口服非甾体抗炎药（NSAID）。尽管各国批准的适应症存在一些差异，但醋氯芬酸主要推荐用于治疗炎症性和疼痛性病症，如腰痛（LBP）、肩周炎、关节外风湿病、牙痛、骨关节炎（OA）、类风湿关节炎（RA）和强直性脊柱炎（AS）。本文综述了醋氯芬酸在肌肉骨骼疾病中的镇痛特性和耐受性，重点关注相关的近期研究。描述了醋氯芬酸与其他镇痛药和抗炎药在OA、AS、RA和LBP中的疗效和安全性比较。通过在PubMed上使用1992年1月1日至2020年1月1日发表的“醋氯芬酸”和“临床试验”等术语进行文献检索，确定了相关研究。在减轻慢性疼痛病症（OA、AS、RA和LBP）的疼痛和/或改善功能能力方面，醋氯芬酸至少与其他NSAIDs一样有效。它通常耐受性良好，并且似乎比其他NSAIDs具有更有利的胃肠道安全性。因此，目前的证据表明，醋氯芬酸是治疗各种疼痛病症中疼痛和炎症的有用选择。
