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长骨骨折后发生脑脂肪栓塞综合征:一例报告。

Cerebral fat embolism syndrome after long bone fracture: A case report.

作者信息

Kassimi Mariam, Amriss Omar, Guerroum Hind, Habi Jihane, Salimi Zakaria, Mahi Mohamed

机构信息

Department of Radiology, Faculty of Medicine, Mohammed VI University of Health Sciences/Cheikh Khalifa International University Hospital, Casablanca, Morocco.

20 Aout Radiology Department of Ibn Rochd University Hospital of Casablanca, Faculty of Medicine and Pharmacy-University Hassan II, Casablanca, Morocco.

出版信息

Radiol Case Rep. 2021 Nov 25;17(2):283-285. doi: 10.1016/j.radcr.2021.10.060. eCollection 2022 Feb.

DOI:10.1016/j.radcr.2021.10.060
PMID:34876950
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8628207/
Abstract

Cerebral fat embolism is a rare and potentially fatal condition that may occur following a long bone fracture. Its characterized by respiratory, neurological, and mucocutaneous signs. Isolated severe brain syndrome remains exceptional. We report a 21-year-old male patient admitted for the cerebral manifestation of a fat embolism syndrome due to a fracture of long bone after a traffic accident injury. Neurological deterioration after a free interval was seen with generalized tonic-clonic seizures. MRI of the brain was indicated which showed numerous multifocal hyperintensities involving the deep white matter of both hemispheres producing a "starfield" appearance. This pattern of cytotoxic cerebral edema, with lesions in the white matter rather than the grey matter, is indicative of the subacute stage of fat embolism. The patient was treated with comprehensive support in the intensive care unit, he returned to normal neurological function and was discharged after 3 weeks of hospitalization.

摘要

脑脂肪栓塞是一种罕见且可能致命的病症,可发生于长骨骨折后。其特征为呼吸、神经及黏膜皮肤体征。孤立的严重脑综合征仍较为罕见。我们报告一名21岁男性患者,因交通事故致长骨骨折后出现脂肪栓塞综合征的脑部表现而入院。在一段无异常期后出现神经功能恶化,并伴有全身强直阵挛发作。遂行脑部MRI检查,结果显示双侧半球深部白质有多处多灶性高信号,呈“星场”样表现。这种以白质而非灰质出现病变的细胞毒性脑水肿模式,提示为脂肪栓塞的亚急性期。该患者在重症监护病房接受了综合支持治疗,恢复了正常神经功能,住院3周后出院。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6990/8628207/e87e3e7a4e9e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6990/8628207/7ffcb27dd485/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6990/8628207/e87e3e7a4e9e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6990/8628207/7ffcb27dd485/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6990/8628207/e87e3e7a4e9e/gr2.jpg

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引用本文的文献

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Occurrence of Numerous Cerebral White Matter Hyperintensities in Trauma Patients With Cerebral Fat Embolism: A Systematic Review and Report of Two Cases.脑脂肪栓塞创伤患者中大量脑白质高信号的发生:一项系统评价及两例报告
Cureus. 2023 Sep 18;15(9):e45450. doi: 10.7759/cureus.45450. eCollection 2023 Sep.
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Do you know the diagnostic importance of susceptibility-weighted imaging on MRI for patients with cerebral fat embolism?你知道磁共振成像(MRI)的 susceptibility-weighted imaging 对脑脂肪栓塞患者的诊断重要性吗?
Clin Case Rep. 2023 Aug 24;11(9):e7813. doi: 10.1002/ccr3.7813. eCollection 2023 Sep.

本文引用的文献

1
Imaging findings of cerebral fat embolism syndrome: a case report.脑脂肪栓塞综合征的影像学表现:一例报告。
J Int Med Res. 2020 Sep;48(9):300060520950559. doi: 10.1177/0300060520950559.
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T2*-Weighted and Diffusion Magnetic Resonance Imaging Differentiation of Cerebral Fat Embolism From Diffuse Axonal Injury.基于T2*加权和扩散磁共振成像鉴别脑脂肪栓塞与弥漫性轴索损伤
J Comput Assist Tomogr. 2017 Nov/Dec;41(6):877-883. doi: 10.1097/RCT.0000000000000635.
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Clinical Features and Neuroimaging Findings in Patients with Cerebral Fat Embolism.
脑脂肪栓塞患者的临床特征及神经影像学表现
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Cerebral fat embolism syndrome after long bone fracture due to gunshot injury.枪伤所致长骨骨折后发生的脑脂肪栓塞综合征
Indian J Crit Care Med. 2014 Mar;18(3):167-9. doi: 10.4103/0972-5229.128707.
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Post-traumatic fulminant paradoxical fat embolism syndrome in conjunction with asymptomatic atrial septal defect: a case report and review of the literature.创伤后暴发性矛盾性脂肪栓塞综合征合并无症状房间隔缺损:一例报告及文献复习
J Med Case Rep. 2011 Apr 10;5:142. doi: 10.1186/1752-1947-5-142.
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Fat embolism syndrome in long bone fracture--clinical experience in a tertiary referral center in Taiwan.长骨骨折脂肪栓塞综合征-台湾一家三级转诊中心的临床经验。
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Cerebral fat embolism: susceptibility-weighted magnetic resonance imaging.脑脂肪栓塞:磁敏感加权磁共振成像
Arch Neurol. 2009 Sep;66(9):1170. doi: 10.1001/archneurol.2009.173.
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Contrast-enhanced MR imaging of cerebral fat embolism: case report and review of the literature.脑脂肪栓塞的对比增强磁共振成像:病例报告及文献复习
AJNR Am J Neuroradiol. 2003 Jan;24(1):97-101.