Department of Orthopedics, Changhai Hospital, Naval Medical University (Second Military Medical University), Shanghai 200433, China.
Department of Orthopedics, The 900th Hospital of Joint Logistic Support Force, Fuzhou, Fujian Province 350025, China.
J Immunol Res. 2021 Nov 28;2021:8970173. doi: 10.1155/2021/8970173. eCollection 2021.
The treatment of bone metastases is a thorny issue. Immunotherapy may be one of the few hopes for patients with unresectable bone metastases. Immune checkpoint inhibitors are the most commonly used immunotherapy drugs currently. In this review, the characteristics and interaction of bone metastases and their immune microenvironment were systematically discussed, and the relevant research progress of the immunological mechanism of tumor bone metastasis was reviewed. On this basis, we expounded the clinical application of immune checkpoint inhibitors for bone metastasis of common tumors, including non-small-cell lung cancer, renal cell carcinoma, prostate cancer, melanoma, and breast cancer. Then, the deficiencies and limitations in current researches were summarized. In-depth basic research on bone metastases and optimization of clinical treatment is needed.
骨转移的治疗是一个棘手的问题。免疫疗法可能是治疗不可切除骨转移患者的少数希望之一。免疫检查点抑制剂是目前最常用的免疫治疗药物。在这篇综述中，系统地讨论了骨转移及其免疫微环境的特征和相互作用，并回顾了肿瘤骨转移免疫机制的相关研究进展。在此基础上，阐述了免疫检查点抑制剂在常见肿瘤骨转移中的临床应用，包括非小细胞肺癌、肾细胞癌、前列腺癌、黑色素瘤和乳腺癌。然后，总结了目前研究中的不足和局限性。需要对骨转移进行深入的基础研究和优化临床治疗。
