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肺癌患者接受全脑放疗和阿替利珠单抗治疗后出现可重现的远隔效应。

Reproducible abscopal effect in a patient with lung cancer who underwent whole-brain irradiation and atezolizumab administration.

机构信息

Department of Internal Medicine, Division of Medical Oncology & Respiratory Medicine, Shimane University, Izumo, Japan.

出版信息

Thorac Cancer. 2021 Mar;12(6):985-988. doi: 10.1111/1759-7714.13875. Epub 2021 Feb 3.

DOI:10.1111/1759-7714.13875
PMID:33538129
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7952789/
Abstract

Due to the emergence of immune checkpoint inhibitors, the abscopal effect has gained more attention. We report a case of extracranial abscopal effect after whole-brain irradiation therapy due to brain metastasis. After the initial abscopal effect was confirmed, a second abscopal effect was confirmed following radiation therapy for bone metastases. This case confirms the reproducibility of the abscopal effect. Moreover, the abscopal effect was not observed in metastatic lesions with low immunogenicity, even in the same patient.

摘要

由于免疫检查点抑制剂的出现，远隔效应引起了更多的关注。我们报告了一例脑转移患者行全脑放疗后发生颅外远隔效应的病例。在最初的远隔效应得到确认后，在对骨转移进行放射治疗后又确认了第二次远隔效应。该病例证实了远隔效应的可重复性。此外，即使在同一患者中，免疫原性低的转移性病变也未观察到远隔效应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d96/7952789/ac8a18f28dd8/TCA-12-985-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d96/7952789/dd41dcd7133a/TCA-12-985-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d96/7952789/49bf5c6d676a/TCA-12-985-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d96/7952789/ac8a18f28dd8/TCA-12-985-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d96/7952789/dd41dcd7133a/TCA-12-985-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d96/7952789/49bf5c6d676a/TCA-12-985-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d96/7952789/ac8a18f28dd8/TCA-12-985-g004.jpg

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