State Key Laboratory of Pharmaceutical Biotechnology, Department of Biotechnology and Pharmaceutical Sciences, School of Life Science, Nanjing University, Nanjing, China.
Biopharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Med Res Rev. 2022 May;42(3):1147-1178. doi: 10.1002/med.21873. Epub 2021 Dec 7.
Andrographolide, a well-known natural lactone having a range of pharmacological actions in traditional Chinese medicine. It has long been used to cure a variety of ailments. In this review, we cover the pharmacokinetics and pharmacological activity of andrographolide which supports its further clinical application in cancers and inflammatory diseases. Growing evidence shows a good therapeutic effect in inflammatory diseases, including liver diseases, joint diseases, respiratory system diseases, nervous system diseases, heart diseases, inflammatory bowel diseases, and inflammatory skin diseases. As a result, the effects of andrographolide on immune cells and the processes that underpin them are discussed. The preclinical use of andrographolide to different organs in response to malignancies such as colorectal, liver, gastric, breast, prostate, lung, and oral cancers has also been reviewed. In addition, several clinical trials of andrographolide in inflammatory diseases and cancers have been summarized. This review highlights recent advances in ameliorating inflammatory diseases as well as cancers by andrographolide and its analogs, providing a new perspective for subsequent research of this traditional natural product.
穿心莲内酯是一种众所周知的天然内酯，在中药中有多种药理作用。它长期以来一直被用于治疗各种疾病。在这篇综述中，我们涵盖了穿心莲内酯的药代动力学和药理学活性，这支持了它在癌症和炎症性疾病中的进一步临床应用。越来越多的证据表明，它在炎症性疾病中具有良好的治疗效果，包括肝脏疾病、关节疾病、呼吸系统疾病、神经系统疾病、心脏病、炎症性肠病和炎症性皮肤病。因此，讨论了穿心莲内酯对免疫细胞及其支撑过程的影响。还综述了穿心莲内酯在不同器官（如结直肠、肝、胃、乳腺、前列腺、肺和口腔癌）对恶性肿瘤的临床前应用。此外，还总结了穿心莲内酯在炎症性疾病和癌症中的几项临床试验。本综述强调了穿心莲内酯及其类似物在改善炎症性疾病和癌症方面的最新进展，为后续对这种传统天然产物的研究提供了新的视角。
