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建立模型并预测大流行导致的总病例数和死亡人数。

Modeling and forecasting the total number of cases and deaths due to pandemic.

机构信息

Department of Statistics, College of Veterinary and Animal Sciences, Jhang, University of Veterinary and Animal Sciences Lahore, Lahore, Pakistan.

Department of Statistics, National College of Business Administration and Economics, Lahore, Pakistan.

出版信息

J Med Virol. 2022 Apr;94(4):1592-1605. doi: 10.1002/jmv.27506. Epub 2021 Dec 18.

Abstract

The COVID-19 pandemic has appeared as the predominant disease of the 21st century at the end of 2019 and was a drastic start with thousands of casualties and the COVID-19 victims in 2020. Due to the drastic effect, COVID-19 scientists are trying to work on pandemic diseases and Governments are interested in the development of methodologies that will minimize the losses and speed up the process of cure by providing vaccines and treatment for such pandemics. The development of a new vaccine for any pandemic requires long in vitro and in vivo trials to use. Thus the strategies require understanding how the pandemic is spreading in terms of affected cases and casualties occurring from this disease, here we developed a forecasting model that can predict the no of cases and deaths due to pandemic and that can help the researcher, government, and other stakeholders to devise their strategies so that the damages can be minimized. This model can also be used for the judicial distribution of resources as it provides the estimates of the number of casualties and number of deaths with high accuracy, Government and policymakers on the basis of forecasted value can plan in a better way. The model efficiency is discussed on the basis of the available dataset of John Hopkins University repository in the period when the disease was first reported in the six countries till the mid of May 2020, the model was developed on the basis of this data, and then it is tested by forecasting the no of deaths and cases for next 7 days, where the proposed strategy provided excellent forecasting. The forecast models are developed for six countries including Pakistan, India, Afghanistan, Iran, Italy, and China using polynomial regression of degrees 3-5. But the models are analyzed up to the 6th-degree and the suitable models are selected based on higher adjusted R-square (R ) and lower root-mean-square error and the mean absolute percentage error (MAPE). The values of R are greater than 99% for all countries other than China whereas for China this R was 97%. The high values of R and Low value of MAPE statistics increase the validity of proposed models to forecast the total no cases and total no of deaths in all countries. Iran, Italy, and Afghanistan also show a mild decreasing trend but the number of cases is far higher than the decrease percentage. Although India is expected to have a consistent result, more or less it depicts some other biasing factors which should be figured out in separate research.

摘要

2019 年底,COVID-19 疫情作为 21 世纪的主要疾病出现,2020 年造成了数千人死亡,成为了一个严峻的开端。由于其剧烈的影响,COVID-19 科学家们正致力于研究传染病,并希望开发出能将损失最小化并加速治疗过程的方法,为这类传染病提供疫苗和治疗。开发任何一种传染病的新疫苗都需要经过长期的体外和体内试验。因此,这些策略需要了解这种传染病是如何传播的,包括受影响的病例和由此病导致的死亡人数。在这里,我们开发了一种可以预测因传染病导致的病例和死亡人数的预测模型,帮助研究人员、政府和其他利益相关者制定策略,以将损失最小化。该模型还可用于司法资源的合理分配,因为它能高精度地提供死亡人数和死亡人数的预估。政府和决策者可以根据预测值更好地进行规划。该模型的有效性是基于约翰霍普金斯大学数据库中疾病首次报告的六个国家在 2020 年 5 月中旬之前的数据进行讨论的,该模型是在这些数据的基础上建立的,然后通过预测未来 7 天的死亡人数和病例数来进行测试,结果显示该模型提供了出色的预测结果。该模型是针对巴基斯坦、印度、阿富汗、伊朗、意大利和中国这六个国家开发的,使用的是 3-5 次多项式回归。但我们对模型进行了分析,最高达到 6 次,并根据调整后的 R 平方(R)更高和均方根误差(Root-Mean-Square Error,RMSE)和平均绝对百分比误差(Mean Absolute Percentage Error,MAPE)更低的原则选择了合适的模型。除中国外,所有国家的 R 值都大于 99%,而中国的 R 值为 97%。R 值高,MAPE 统计数据低,增加了模型预测所有国家总病例数和总死亡人数的有效性。伊朗、意大利和阿富汗也呈现出温和的下降趋势,但病例数仍远高于下降比例。尽管印度预计会有一个一致的结果,但它或多或少地反映了一些其他的偏差因素,这些因素应该在单独的研究中加以解决。

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本文引用的文献

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Likelihood of survival of coronavirus disease 2019.2019冠状病毒病的生存可能性。
Lancet Infect Dis. 2020 Jun;20(6):630-631. doi: 10.1016/S1473-3099(20)30257-7. Epub 2020 Mar 30.

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