在社会统治管测试中，活双歧杆菌、乳杆菌和链球菌的联合使用改善了竞争型小鼠的社会等级地位并缓解了其焦虑样行为。
The combination of living Bifidobacterium, Lactobacillus, and Streptococcus improves social ranking and relieves anxiety-like behaviors in competitive mice in a social dominance tube test.
机构信息
School of Basic Medical Sciences, Kunming Medical University, Kunming, Yunnan, P. R. China.
School of Pharmaceutical Science, Department of Zoology & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, Yunnan, P. R. China.
出版信息
Brain Behav. 2022 Jan;12(1):e2453. doi: 10.1002/brb3.2453. Epub 2021 Dec 8.
INTRODUCTION
Social rank has a profound influence on the behavior and health of humans and animals.
METHODS
To explore the effect of a combination of living Bifidobacterium, Lactobacillus and Streptococcus (CLB) on anxiety- and depression-like behaviors and social rank, mice were subjected to a social dominance tube test (SDTT). The behaviors, rank, gut microbiota, and expression of inflammatory cytokines and brain-derived neurotrophic factor (BDNF) in the hippocampus were measured.
RESULTS
The results indicated that CLB improved the SDTT ranking score of the losers and alleviated anxiety-like behaviors of the winners. CLB decreased the level of Desulfovibrio and augmented the level of Mollicutes in the feces, increased BDNF content, and reduced the level of tumor necrosis factor-α in the hippocampus.
CONCLUSION
These findings indicated that CLB may be used for the treatment of anxiety and improvement of the rank score via regulation of gut microbiota and anti-inflammatory effects.
简介
社会等级对人类和动物的行为和健康有深远影响。
方法
为了探究组合双歧杆菌、乳酸菌和链球菌（CLB）对焦虑和抑郁样行为及社会等级的影响，我们对小鼠进行了社会优势管测试（SDTT）。测量了行为、等级、肠道微生物群以及海马体中炎症细胞因子和脑源性神经营养因子（BDNF）的表达。
结果
结果表明，CLB 提高了失败者的 SDTT 排名得分，并缓解了胜利者的焦虑样行为。CLB 降低了粪便中脱硫弧菌的水平，增加了 Mollicutes 的水平，增加了 BDNF 含量，降低了海马体中肿瘤坏死因子-α的水平。
结论
这些发现表明，CLB 可能通过调节肠道微生物群和抗炎作用，用于治疗焦虑症和提高等级评分。
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