Association between Depression, Anxiety Symptoms and Gut Microbiota in Chinese Elderly with Functional Constipation.

UNLABELLED

This study aimed to investigate the relationship between anxiety, depression, and gut microbiota in elderly patients with FC.

METHODS

in this cross-sectional study, a total of 198 elderly participants (85 male and 113 female) aged over 60 years were recruited. The study was conducted in Changsha city, China. The participants completed an online questionnaire, including The Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), The Patient Assessment of Symptoms (PAC-SYM), and The Patient Assessment of Quality of Life (PAC-QoL). We selected the 16S rDNA V3 + V4 region as the amplification region and sequenced the gut microbiota using the Illumina Novaseq PE250 high-throughput sequencing platform.

RESULTS

in total, 30.3% of patients with constipation had depression, while 21.3% had anxiety. The relative abundance of intestinal microbiota in the normal group was higher than that in the anxiety and depression group. According to LEfSe analysis, the relative abundance of and in the people without depression and anxiety was higher. The relative abundance of and in the depression group was lower, and the relative abundance of and in the anxiety group was higher. In addition, according to the correlation analysis, and were negatively correlated with constipation symptoms, anxiety, and depression.

CONCLUSIONS

this study found that gut microbiota composition may be associated with a higher incidence of anxiety and depression in patients with FC, thus providing insight into the mechanisms that ameliorate mood disorders in patients with FC.