Manzo Ciro
Rheumatology Outpatient Clinic, Poliambulatorio "Mariano Lauro", Sant'Agnello-Distretto Sanitario 59 (Penisola Sorrentina), ASL Napoli 3 sud, 80065 Sant'Agnello, Naples, Italy.
Med Sci (Basel). 2019 Aug 30;7(9):92. doi: 10.3390/medsci7090092.
to evaluate incidence and prevalence rates of polymyalgia rheumatica (PMR) in Italy, depending on the epidemiological methodology used from time to time.
A comprehensive literature search in MEDLINE and EMBASE was carried out. The following search terms were used: polymyalgia rheumatica, incidence, prevalence, epidemiology, general practitioner, family medicine, Italy. A search was also carried out in Google scholar using the search phrase: epidemiology of polymyalgia rheumatica in Italy. The period considered was between 1970 and March 2019. All articles containing data on incidence and prevalence of PMR in Italy were read in full. Reviews and non-original manuscripts were excluded as well as all the studies containing incidence and prevalence rates of giant cell arteritis (GCA), unless clearly distinct from data related to patients with PMR alone (isolated and pure PMR).
Five articles corresponded to inclusion and exclusion criteria. Two articles were excluded as they were review articles, and three articles were excluded because there were not clear data on incidence and prevalence rates of isolated PMR. Three articles reported data on the annual incidence of PMR (two of them published by the same group of investigators); two articles reported prevalence data. In one article, both incidence and prevalence were calculated. The annual rate of incidence of PMR was between 0.12 and 2.3 cases/1000 inhabitants aged over 50 years. In the two studies publishing prevalence data, they varied from 0.37% to 0.62%. The differences in incidence and prevalence rates were related to several factors such as the different set of diagnostic criteria used for identifying patients or the diagnostic difficulty for patients with atypical presentations, specifically those without raised erythrocyte sedimentation rate (ESR). In the study with higher annual rate of incidence and higher prevalence of PMR, the collaboration between general practitioner (GP) and the out-of-hospital public rheumatologist resulted in significantly different data than in the other studies. All the five articles presented data from monocentric cohorts.
Very few Italian studies addressed the epidemiology of PMR. The contribution of a specific professional figure represented by the out-of-hospital public rheumatologist, present in the Italian National Health System and absent in other countries, can make the Italian experience unique in its kind.
根据不同时期使用的流行病学方法，评估意大利风湿性多肌痛（PMR）的发病率和患病率。
在MEDLINE和EMBASE中进行全面的文献检索。使用了以下检索词：风湿性多肌痛、发病率、患病率、流行病学、全科医生、家庭医学、意大利。还在谷歌学术中使用搜索短语“意大利风湿性多肌痛的流行病学”进行了搜索。所考虑的时间段为1970年至2019年3月。阅读了所有包含意大利PMR发病率和患病率数据的文章。排除综述和非原创手稿，以及所有包含巨细胞动脉炎（GCA）发病率和患病率的研究，除非与仅患有PMR的患者（孤立性和单纯性PMR）的数据明显不同。
五篇文章符合纳入和排除标准。两篇文章因是综述文章而被排除，三篇文章因没有关于孤立性PMR发病率和患病率的明确数据而被排除。三篇文章报告了PMR的年发病率数据（其中两篇由同一组研究人员发表）；两篇文章报告了患病率数据。在一篇文章中，计算了发病率和患病率。PMR的年发病率在每1000名50岁以上居民中为0.12至2.3例。在两项公布患病率数据的研究中，患病率在0.37%至0.62%之间。发病率和患病率的差异与几个因素有关，如用于识别患者的不同诊断标准集，或非典型表现患者的诊断困难，特别是那些红细胞沉降率（ESR）未升高的患者。在PMR年发病率和患病率较高的研究中，全科医生（GP）与院外公共风湿病学家之间的合作产生的数据与其他研究有显著差异。所有五篇文章均提供了单中心队列的数据。
很少有意大利研究涉及PMR的流行病学。意大利国家卫生系统中存在而其他国家没有的由院外公共风湿病学家代表的特定专业人员的贡献，可能使意大利的经验独具特色。
