氯化锂抑制传染性支气管炎病毒诱导的细胞凋亡和炎症。
Lithium chloride inhibits infectious bronchitis virus-induced apoptosis and inflammation.
机构信息
Livestock and Poultry Healthy Breeding Research Sub-center of Biochip Beijing Engineering Research Center, Department of Veterinary Medicine, Beijing University of Agriculture, Beijing, People's Republic of China.
Livestock and Poultry Healthy Breeding Research Sub-center of Biochip Beijing Engineering Research Center, Department of Veterinary Medicine, Beijing University of Agriculture, Beijing, People's Republic of China.
出版信息
Microb Pathog. 2022 Jan;162:105352. doi: 10.1016/j.micpath.2021.105352. Epub 2021 Dec 7.
Avian infectious bronchitis (IB) was caused by infectious bronchitis virus (IBV), a coronavirus, which leads to enormous economic losses in the poultry industry. Studies have shown that lithium chloride (LiCl) is a good virus inhibitor. Through cell culture, virus infection, and RT-qPCR, we found that LiCl could down-regulate the apoptosis-related genes Caspase-3 and Bax, up-regulate Bcl-2, and down-regulate the inflammatory-related genes (NF-κB, NLRP3, TNF-α, and IL-1β) via inhibiting virus replication. Finally, clinical trials showed that LiCl could inhibit IBV-induced apoptosis and inflammatory in chicken embryos as well as reduce the mortality and deformity rate of chicken embryos. The results showed that LiCl has antiviral activity against IBV and clinical effects. Further studies are required to explore the exact action mechanism of LiCl on IBV-induced apoptosis and inflammation.
鸡传染性支气管炎（IB）是由传染性支气管炎病毒（IBV）引起的，冠状病毒，这会给家禽业带来巨大的经济损失。研究表明，氯化锂（LiCl）是一种良好的病毒抑制剂。通过细胞培养、病毒感染和 RT-qPCR，我们发现 LiCl 可以通过抑制病毒复制来下调凋亡相关基因 Caspase-3 和 Bax，上调 Bcl-2，并下调炎症相关基因（NF-κB、NLRP3、TNF-α 和 IL-1β）。最后，临床试验表明，LiCl 可以抑制 IBV 诱导的鸡胚凋亡和炎症，降低鸡胚死亡率和畸形率。结果表明，LiCl 对 IBV 具有抗病毒活性和临床效果。需要进一步研究来探讨 LiCl 对 IBV 诱导的凋亡和炎症的确切作用机制。
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