Constituents from the Fruiting Bodies of and in Vietnam and Their Anti-Inflammatory Bioactivity.

It is reported that various fungi have been used for medicine and edible foods. The tropical genus is popular and well-known in Vietnam for its health effects and bioactivities. In this study, the fruiting bodies of the edible fungi and were collected in Vietnam. The preliminary bioactivity screening data indicated that the methanol extracts of the fruiting bodies of and displayed significant inhibition of superoxide anion generation and elastase release in human neutrophils. Therefore, the isolation and characterization were performed on these two species by a combination of chromatographic methods and spectrometric analysis. In total, twenty-four compounds were identified, and among these () were characterized by 1D-, 2D-NMR, and HRMS analytical data. In addition, the anti-inflammatory potentials of some purified compounds were examined by the cellular model for the inhibition of superoxide anion generation and elastase release in human neutrophils. Among the isolated compounds, (,), and () displayed significant anti-inflammatory potential. As the results suggest, the extracts and isolated compounds from and are potential candidates for the further development of new anti-inflammatory lead drugs or natural healthy foods.