灵芝中的三萜类和甾体化合物及其对超氧阴离子生成和弹性蛋白酶释放的抑制作用。
Triterpenoids and steroids from Ganoderma mastoporum and their inhibitory effects on superoxide anion generation and elastase release.
机构信息
Department of Chemistry, Vinh University, Vinh City, Nghe An 42000, Vietnam.
出版信息
Molecules. 2013 Nov 19;18(11):14285-92. doi: 10.3390/molecules181114285.
The methanol extracts of the fruiting bodies of Ganoderma mastoporum collected in Vietnam was purified to afford eight compounds, including three triterpenoids and five steroids. The purified compounds were examined for their inhibitory effects against superoxide anion generation and elastase release. Among the tested compounds, ergosta-4,6,8(14),22-tetraen-3-one (3) exhibited the most significant inhibition towards superoxide anion generation and elastase release with IC50 values of 2.30 ± 0.38 and 1.94 ± 0.50 µg/mL, respectively.
越产树舌子实体甲醇提取物经纯化得到 8 种化合物，包括 3 种三萜和 5 种甾体。对纯化的化合物进行了对超氧阴离子生成和弹性蛋白酶释放的抑制作用的检测。在所测试的化合物中，麦角甾-4,6,8(14),22-四烯-3-酮（3）对超氧阴离子生成和弹性蛋白酶释放的抑制作用最为显著，IC50 值分别为 2.30±0.38 和 1.94±0.50μg/mL。
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