de Meglio P, Ravenna F, Carenini G, Gentili P, Gabbiati G T, Riva M
Farmaco Sci. 1984 Dec;39(12):1024-37.
Some N-acylated derivatives of cyclohexylaniline were prepared. These can be considered as derived from oxarbazol (A), a carbazolic structure with antiallergic activity, by breaking the bond between carbon atom 4a and 4b. In the new molecule the following groups were introduced: benzoic acid, salicylic acid, acetylsalicylic acid and tetrazol. The synthesized compounds were studied for analgesic, antiedema and antiallergic activity. Some showed analgesic action (phenylquinone) comparable with that of naproxen. Antiinflammatory activity was slight and antiallergic activity nonexistent.
制备了一些环己基苯胺的N-酰化衍生物。这些衍生物可被认为是由具有抗过敏活性的咔唑结构恶唑巴唑（A）通过断裂4a碳原子和4b碳原子之间的键衍生而来。在新分子中引入了以下基团：苯甲酸、水杨酸、乙酰水杨酸和四氮唑。对合成的化合物进行了镇痛、抗水肿和抗过敏活性研究。一些化合物显示出与萘普生相当的镇痛作用（苯基醌）。抗炎活性轻微，抗过敏活性不存在。
