长期体外克隆或未克隆的细胞毒性T淋巴细胞的自我保护。
Self-sparing of long-term in vitro-cloned or uncloned cytotoxic T lymphocytes.
作者信息
Luciani M F, Brunet J F, Suzan M, Denizot F, Golstein P
出版信息
J Exp Med. 1986 Sep 1;164(3):962-7. doi: 10.1084/jem.164.3.962.
Abstract
At least some long-term in vitro-cultured cytotoxic T cell clones and uncloned cell populations are able, in the presence of Con A, to lyse other cells, to be lysed by other cells, but not to lyse themselves. This as-yet-unexplained result may have implications as to the mechanism of T cell-mediated cytotoxicity.
摘要
至少一些长期体外培养的细胞毒性T细胞克隆和未克隆的细胞群体，在有刀豆蛋白A存在的情况下，能够裂解其他细胞，也能被其他细胞裂解，但不会裂解自身。这一尚未得到解释的结果可能对T细胞介导的细胞毒性机制具有启示意义。
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本文引用的文献
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Immunogenetics. 1982;16(6):533-49. doi: 10.1007/BF00372022.
2
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Scand J Immunol. 1982 Jun;15(6):619-25. doi: 10.1111/j.1365-3083.1982.tb00691.x.
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