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长期体外克隆或未克隆的细胞毒性T淋巴细胞的自我保护。

Self-sparing of long-term in vitro-cloned or uncloned cytotoxic T lymphocytes.

作者信息

Luciani M F, Brunet J F, Suzan M, Denizot F, Golstein P

出版信息

J Exp Med. 1986 Sep 1;164(3):962-7. doi: 10.1084/jem.164.3.962.

DOI:10.1084/jem.164.3.962
PMID:3489065
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2188387/
Abstract

At least some long-term in vitro-cultured cytotoxic T cell clones and uncloned cell populations are able, in the presence of Con A, to lyse other cells, to be lysed by other cells, but not to lyse themselves. This as-yet-unexplained result may have implications as to the mechanism of T cell-mediated cytotoxicity.

摘要

至少一些长期体外培养的细胞毒性T细胞克隆和未克隆的细胞群体，在有刀豆蛋白A存在的情况下，能够裂解其他细胞，也能被其他细胞裂解，但不会裂解自身。这一尚未得到解释的结果可能对T细胞介导的细胞毒性机制具有启示意义。

相似文献

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引用本文的文献

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本文引用的文献

1
Interactions between MHC-encoded products and cloned T-cells. I. Fine specificity of induction of proliferation and lysis.主要组织相容性复合体（MHC）编码产物与克隆化T细胞之间的相互作用。I. 增殖与裂解诱导的精细特异性
Immunogenetics. 1982;16(6):533-49. doi: 10.1007/BF00372022.
2
Characterization of an Lyt-1+ cytolytic T-cell clone specific for a polymorphic domain of the I-Ak molecule.一种针对I-Ak分子多态性结构域的Lyt-1+细胞溶解性T细胞克隆的特性分析。
Scand J Immunol. 1982 Jun;15(6):619-25. doi: 10.1111/j.1365-3083.1982.tb00691.x.
3
Cytolytic T cell hybridomas. I. Interleukin 2-independent noncytolytic variants.细胞溶解性T细胞杂交瘤。I. 白细胞介素2非依赖性非细胞溶解性变体。
Eur J Immunol. 1985 Aug;15(8):751-5. doi: 10.1002/eji.1830150802.
4
Is the T-cell receptor involved in T-cell killing?T细胞受体是否参与T细胞杀伤作用？
Nature. 1986;319(6056):778-80. doi: 10.1038/319778a0.
5
Studies on the mechanism of lymphocyte-mediated cytolysis. IX. Relationships between antigen recognition and lytic expression in killer T cells.淋巴细胞介导的细胞溶解机制研究。IX. 杀伤性T细胞中抗原识别与裂解表达之间的关系。
J Immunol. 1977 Jan;118(1):71-6.