To establish and compare the prediction effect of SES and SARIMA model, and select the best prediction model to predict the number of patients in neurology department. The data came from HIS and medical record management system of a Grade-A hospital in Zhejiang Province. The number of inpatients from January 2019 to September 2023 was selected to establish SES and SARIMA model, respectively. Compare the fitting parameters, The larger the R_adjusted, R, the smaller the RMSE, MAPE, MAE and standardized BIC, The better model is selected. Finally, the established model was used to predict the number of hospital admissions from October to December 2023, and the prediction effect of the MRE judgment model was compared. The number of admissions to the department of neurology shows a cyclical change, and drops sharply in January-February each year and rises rapidly in March. The best fitting models of SES model and SARIMA model were Winters addition model and SARIMA(0,1,1)(0,1,1) model, respectively. The two models were selected to predict the number of admissions in the Department of neurology from October to December 2023, and the average relative error was 0.04 and 0.03, respectively. The prediction effect of SARIMA(0,1,1)(0,1,1) model was better. Age and Spring Festival may be the factors that affect the periodic change of the number of admissions in neurology department. Both SES and SARIMA model can be used to predict the number of admissions in the department of neurology, and the SARIMA model may be better.