Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:5433-5436. doi: 10.1109/EMBC46164.2021.9629895.
Atherosclerosis is a chronic inflammatory disease associated with heart attack and stroke. It causes the growth of atherosclerotic plaques inside the arterial vessels, which in turn results to the reduction of the blood flow to the different organs. Drug-Eluting Stents (DES) are mesh-like wires, carrying pharmaceutical coating, designed to dilate and support the arterial vessel, restore blood flow and through the controlled local drug delivery inhibit neo-intimal thickening. In silico modeling is an efficient method of accurately predicting and assessing the performance of the stenting procedure. The present in silico study investigates the performance of two different stents (Bare Metal Stent, Drug-Eluting Stent) in a patient-specific coronary artery and assesses the effect of stent coating, considering that the same procedural approach is followed by the interventional cardiologist. The results demonstrate that even if small differences are obtained in the two models, the incorporation of the stent coatings (in DES) does not significantly affect the outcomes of the stent deployment, the stresses and strains in the scaffold and the arterial tissue. Nevertheless, it is suggested that regarding the DES expansion, higher pressure should be applied at the inner surface of the stent.
动脉粥样硬化是一种与心脏病发作和中风有关的慢性炎症性疾病。它会导致动脉血管内动脉粥样硬化斑块的生长，从而导致流向不同器官的血液减少。药物洗脱支架 (DES) 是一种带有药物涂层的网状金属丝，旨在扩张和支撑动脉血管，恢复血流，并通过控制局部药物输送来抑制新内膜增厚。计算机模拟是一种准确预测和评估支架置入术性能的有效方法。本计算机研究调查了两种不同支架（金属裸支架、药物洗脱支架）在特定患者冠状动脉中的性能，并评估了支架涂层的效果，因为介入心脏病专家采用相同的手术方法。结果表明，即使在两个模型中获得了微小的差异，支架涂层的加入（在 DES 中）并不会显著影响支架扩张的结果、支架和动脉组织中的应力和应变。然而，建议在 DES 扩张时，应在支架的内表面施加更高的压力。
