Psarras Spyridon, Skafidas Anargyros-Nektarios, Kostopoulos Vassilis
Department of Mechanical Engineering and Aeronautics, University of Patras, 26504 Patras, Greece.
Biomedicines. 2024 Sep 14;12(9):2105. doi: 10.3390/biomedicines12092105.
The reduction in the inner diameter of the artery due to the creation of atheromatic plaque on the artery lumen, known as artery stenosis, disrupts the blood flow, leading to medical complications, which can be fatal. The angioplasty procedure aims to reopen the artery and uses a stent to keep it open. In this study, an effort is made to determine the point of the stent, the plaque and the artery during the expansion phase of the angioplasty using the in silico Finite Element Analysis method. A literature-based design was chosen for the stent geometry, whereas simplified shapes of the balloon and the two artery layers were used. Additionally, two plaque designs were the benchmark for the eight distinct artery stenosis models within the Abaqus environment. In the context of stent angioplasty simulations, failure patterns were investigated. An inverse relationship was observed between artery stenosis and pressure at the artery failure point, while an increased danger of interlaminar failure was detected in models with larger artery stenosis. This study verifies the necessity for the inclusion of interlaminar failure in future angioplasty research.
动脉内腔上形成动脉粥样硬化斑块导致动脉内径减小，即动脉狭窄，会扰乱血流，引发医学并发症，甚至可能致命。血管成形术旨在重新开通动脉，并使用支架使其保持通畅。在本研究中，采用计算机模拟有限元分析方法，努力确定血管成形术扩张阶段支架、斑块和动脉的位置。支架几何形状采用基于文献的设计，而球囊和两层动脉则使用简化形状。此外，在Abaqus环境中，两种斑块设计是八个不同动脉狭窄模型的基准。在支架血管成形术模拟中，研究了失效模式。观察到动脉狭窄与动脉失效点处的压力呈反比关系，而在动脉狭窄较大的模型中检测到层间失效的危险增加。本研究证实了在未来血管成形术研究中纳入层间失效的必要性。
