类风湿性滑液中免疫复合物的特性与反应性
Properties and reactivity of immune complexes in rheumatoid synovial fluid.
作者信息
Mochan E, Passon T J
出版信息
Rheumatol Int. 1986;6(3):103-9. doi: 10.1007/BF00270345.
Fractionation of immune complexes (IC) from rheumatoid synovial fluid revealed the presence of three different fractions of IC. The largest molecular weight form, fraction I (above 1000 Kdaltons) was predominately composed of IgG and IgM and contained both IgM-RF and IgG-RF. The other IC, fraction II (480 Kdaltons) and fraction III (330 Kdaltons), contained predominately IgG with some IgA and only significant amounts of IgG-RF. All three fractions of IC can bind Clq and stimulate human monocyte prostaglandin E (PGE) production. Fraction I IC bound Clq most readily while fraction III IC were the most effective stimulators of monocyte PGE production. IC stimulation of monocyte PGE production was inhibited by staphylococcus protein A suggesting mediation via activation of Fc receptors. It remains to be determined whether this IC reactivity has any pathologic significance.
对类风湿性滑液中的免疫复合物（IC）进行分级分离后发现存在三种不同的IC组分。分子量最大的形式，即组分I（高于1000千道尔顿）主要由IgG和IgM组成，同时含有IgM类风湿因子（IgM-RF）和IgG类风湿因子（IgG-RF）。其他IC，即组分II（480千道尔顿）和组分III（330千道尔顿），主要含有IgG以及一些IgA，并且仅含有大量的IgG-RF。所有这三种IC组分都能结合Clq并刺激人单核细胞前列腺素E（PGE）的产生。组分I的IC最容易结合Clq，而组分III的IC是单核细胞PGE产生的最有效刺激物。葡萄球菌蛋白A可抑制IC对单核细胞PGE产生的刺激作用，提示其通过Fc受体激活介导。这种IC反应性是否具有任何病理意义仍有待确定。
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