Darvell Brian W, Smith Anthony J
Dental Materials Science, School of Dentistry, University of Birmingham, UK.
School of Dentistry, University of Birmingham, UK.
Dent Mater. 2022 Jan;38(1):2-6. doi: 10.1016/j.dental.2021.11.002. Epub 2021 Dec 7.
To clarify the terminology and its application in the context of materials placed in contact with tissues in living systems.
Review the nature of both the biological and chemical reactions occurring in such contexts with a view to a classification of types of behaviour and thus types of material.
A range of types of behaviour was identified with clear diagnostic characteristics. Materials could thus be classified accordingly, with the possibility of more than one type of behaviour being exhibited. 'Bioactivity' was concluded to depend solely on the modulation of a natural biological process, but excluding pharmaceutical action.
Clarity in the characterisation and labelling of materials and their behaviours in biological systems will benefit the interpretation of the literature, the design of experiments, and future research directions.
明确在活体系统中与组织接触的材料相关术语及其应用。
审视在此类情况下发生的生物和化学反应的本质，以期对行为类型进而对材料类型进行分类。
确定了一系列具有明确诊断特征的行为类型。材料因此可据此分类，且可能呈现不止一种行为类型。得出结论：“生物活性”仅取决于对自然生物过程的调节，但不包括药物作用。
生物系统中材料及其行为的表征和标记清晰化，将有助于文献解读、实验设计及未来研究方向。
