拟杆菌属在肠道感染中的双重角色。
The ambivalent role of Bacteroides in enteric infections.
机构信息
Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), D-97080 Würzburg, Germany.
Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), D-97080 Würzburg, Germany; Institute of Molecular Infection Biology (IMIB), University of Würzburg, D-97080 Würzburg, Germany.
出版信息
Trends Microbiol. 2022 Feb;30(2):104-108. doi: 10.1016/j.tim.2021.11.009. Epub 2021 Dec 8.
Bacteroides spp. are increasingly used as model gut commensals in cocolonization studies with enteropathogens. The collective findings imply common themes of colonization resistance but also pathogen crossfeeding. We discuss how cutting-edge transcriptomics may help to disentangle the molecular basis of the divergent roles of Bacteroides in either protecting against or promoting infection.
拟杆菌属（Bacteroides spp.）越来越多地被用作共生定植研究中肠共生菌的模型。这些综合研究结果暗示了定植抗性的共同主题，但也提示了病原体的交叉喂养。我们讨论了如何利用前沿的转录组学来帮助阐明拟杆菌在保护或促进感染方面的不同作用的分子基础。
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