Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.
Vet Anaesth Analg. 2022 Jan;49(1):36-44. doi: 10.1016/j.vaa.2021.10.002. Epub 2021 Oct 30.
To compare the effects of sevoflurane, propofol and alfaxalone on the neuromuscular blockade induced by a single intravenous bolus of rocuronium in dogs.
A randomized, prospective, crossover experimental study.
A total of eight adult Beagle dogs (four female, four male), weighing 8.9-15.3 kg and aged 5-7 years.
The dogs were anesthetized three times with 1.25× minimum alveolar concentration of sevoflurane (SEVO treatment) and 1.25× minimum infusion rate of propofol (PROP treatment) or alfaxalone (ALFX treatment) at intervals of ≥14 days. Neuromuscular function was monitored with train-of-four (TOF) stimulation of the peroneal nerve by acceleromyography. After recording the control TOF ratio (TOFRC), a single bolus dose of rocuronium (1 mg kg) was administered intravenously. The times from rocuronium administration to achieving TOF count 0 (onset time), from achieving TOF count 0 to the reappearance of TOF count 4 (clinical blockade period), from 25% to 75% of TOFRC (recovery index) and from achieving TOF count 0 to TOF ratio/TOFRC >0.9 (total neuromuscular blockade duration) were recorded.
The onset time and recovery index did not differ among the treatments. The median clinical blockade period was longer in the SEVO treatment [27.3 (26.0-30.3) minutes] than in PROP [16.6 (15.4-18.0) minutes; p = 0.002] and ALFX [22.4 (18.6-23.1) minutes; p = 0.017] treatments; and longer in the ALFX treatment than in the PROP treatment (p = 0.020). The mean total neuromuscular blockade duration was longer in the SEVO treatment (43.7 ± 9.9 minutes) than in PROP (25.1 ± 2.7 minutes; p < 0.001) and ALFX (32.5 ± 8.4 minutes; p = 0.036) treatments.
Compared with alfaxalone and propofol, sevoflurane prolonged rocuronium-induced neuromuscular blockade by a significantly greater extent in dogs.
比较七氟醚、丙泊酚和阿法沙龙单次静脉推注罗库溴铵诱导犬神经肌肉阻滞的效果。
随机、前瞻性、交叉实验研究。
8 只成年比格犬（4 雌 4 雄），体重 8.9-15.3kg，年龄 5-7 岁。
犬麻醉 3 次，分别为 1.25×七氟醚最低肺泡浓度（SEVO 处理）、1.25×丙泊酚最低输注率（PROP 处理）和阿法沙龙（ALFX 处理），间隔时间≥14 天。通过肌动描记术监测胫神经的四串刺激（TOF）来监测神经肌肉功能。记录对照 TOF 比（TOFRC）后，静脉推注罗库溴铵 1mg/kg。记录从罗库溴铵给药到达到 TOF 计数 0（起效时间）、从达到 TOF 计数 0 到 TOF 计数 4 重现（临床阻滞期）、从 25%到 75%的 TOFRC（恢复指数）以及从达到 TOF 计数 0 到 TOF 比/TOFRC>0.9（总神经肌肉阻滞持续时间）的时间。
3 种处理方式的起效时间和恢复指数无差异。SEVO 处理的中位临床阻滞期较长[27.3（26.0-30.3）分钟]，高于 PROP [16.6（15.4-18.0）分钟；p=0.002]和 ALFX [22.4（18.6-23.1）分钟；p=0.017]处理；ALFX 处理也长于 PROP 处理（p=0.020）。SEVO 处理的平均总神经肌肉阻滞持续时间较长（43.7±9.9 分钟），高于 PROP（25.1±2.7 分钟；p<0.001）和 ALFX（32.5±8.4 分钟；p=0.036）处理。
与阿法沙龙和丙泊酚相比，七氟醚在犬中显著延长了罗库溴铵诱导的神经肌肉阻滞作用。
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