罗库溴铵在犬氟烷麻醉期间的 ED 和 ED95。

ED and ED of rocuronium during alfaxalone anesthesia in dogs.

机构信息

Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.

出版信息

Vet Anaesth Analg. 2023 May;50(3):204-210. doi: 10.1016/j.vaa.2023.02.008. Epub 2023 Feb 17.

DOI:10.1016/j.vaa.2023.02.008

PMID:36967325

Abstract

OBJECTIVE

To determine the median effective dose (ED) and effective dose required to depress the twitch value by 95% (ED) of rocuronium during alfaxalone anesthesia in dogs.

STUDY DESIGN

A randomized, prospective, crossover experimental study.

ANIMALS

A total of eight adult Beagle dogs (four female, four male), weighing 10.3-14.6 kg and aged 6-8 years.

METHODS

The dogs were anesthetized three times with 1.25-fold the individual minimum infusion rate of alfaxalone at intervals of ≥ 14 days. Neuromuscular function was monitored with train-of-four (TOF) stimulation of the peroneal nerve by acceleromyography. After recording the control TOF ratio (TOFRC) and first twitch of TOF (T1C), a single bolus dose of rocuronium 100, 175 or 250 μg kg (treatments R100, R175 or R250) was administered intravenously. The maximum suppression of the first twitch of TOF (T1) was recorded and calibrated with T1C to construct the dose-response curve, from which ED and ED were calculated. Time from rocuronium administration to TOF ratio/TOFRC > 0.9 (duration TOFR0.9) was recorded.

RESULTS

ED and ED of rocuronium during alfaxalone anesthesia were 175 and 232 μg kg, respectively. The median (range) duration TOFR0.9 was longer in treatment R250 [10.1 (9.2-10.9) minutes] than in treatments R100 [3.1 (2.9-4.4) minutes; p < 0.0001] and R175 [7.7 (6.9-8.1) minutes; p < 0.0001]; and longer in treatment R175 than in treatment R100 (p < 0.0001).

CONCLUSIONS AND CLINICAL RELEVANCE

The duration of TOFR0.9 correlated positively with the dosage of rocuronium, indicating that recovery time of rocuronium was also dose-dependent in dogs anesthetized with alfaxalone. The duration TOFR0.9 of rocuronium 250 μg kg was 10 minutes during alfaxalone anesthesia in dogs.

摘要

目的

确定氟烷麻醉犬罗库溴铵的半数有效剂量（ED）和抑制 twitch 值 95%所需的有效剂量（ED）。

研究设计

一项随机、前瞻性、交叉实验研究。

动物

8 只成年比格犬（4 雌 4 雄），体重 10.3-14.6kg，年龄 6-8 岁。

方法

每只犬间隔≥14 天，用氟烷个体最小输注率的 1.25 倍麻醉 3 次。通过肌动描记术监测胫神经的四串（TOF）刺激的神经肌肉功能。记录对照 TOF 比（TOFRC）和 TOF 的第一 twitch（T1C）后，静脉注射罗库溴铵 100、175 或 250μgkg（处理 R100、R175 或 R250）。记录并校准 T1C 以构建剂量反应曲线，从而计算出 ED 和 ED。记录从罗库溴铵给药到 TOF 比/TOFRC>0.9（TOFR0.9 持续时间）的时间。

结果

氟烷麻醉期间罗库溴铵的 ED 和 ED 分别为 175 和 232μgkg。处理 R250 的 TOFR0.9 中位数（范围）持续时间较长[10.1（9.2-10.9）分钟]，明显长于处理 R100[3.1（2.9-4.4）分钟；p<0.0001]和 R175[7.7（6.9-8.1）分钟；p<0.0001]；处理 R175 也长于处理 R100（p<0.0001）。