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IRON MAN interacts with BRUTUS to maintain iron homeostasis in .铁调素与 BRUTUS 相互作用以维持. 中的铁稳态。
Proc Natl Acad Sci U S A. 2021 Sep 28;118(39). doi: 10.1073/pnas.2109063118.
2
Oryza sativa FER-LIKE FE DEFICIENCY-INDUCED TRANSCRIPTION FACTOR (OsFIT/OsbHLH156) interacts with OsIRO2 to regulate iron homeostasis.水稻 FER-LIKE FE DEFICIENCY-INDUCED TRANSCRIPTION FACTOR（OsFIT/OsbHLH156）与 OsIRO2 相互作用，共同调节铁稳态。
J Integr Plant Biol. 2020 May;62(5):668-689. doi: 10.1111/jipb.12933.
3
bHLH121 Functions as a Direct Link that Facilitates the Activation of FIT by bHLH IVc Transcription Factors for Maintaining Fe Homeostasis in Arabidopsis.bHLH121 作为一个直接的连接点，促进了 FIT 的激活，由 bHLH IVc 转录因子维持拟南芥铁的内稳态。
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4
Mobility and localization of the iron deficiency-induced transcription factor bHLH039 change in the presence of FIT.在存在FIT的情况下，缺铁诱导的转录因子bHLH039的移动性和定位会发生变化。
Plant Direct. 2019 Dec 23;3(12):e00190. doi: 10.1002/pld3.190. eCollection 2019 Dec.
5
The iron deficiency response in requires the phosphorylated transcription factor URI.需要磷酸化转录因子 URI 来响应中的铁缺乏。
Proc Natl Acad Sci U S A. 2019 Dec 10;116(50):24933-24942. doi: 10.1073/pnas.1916892116. Epub 2019 Nov 27.
6
The Transcription Factor bHLH121 Interacts with bHLH105 (ILR3) and Its Closest Homologs to Regulate Iron Homeostasis in Arabidopsis.转录因子 bHLH121 与 bHLH105（ILR3）及其最接近的同源物相互作用，以调节拟南芥中的铁稳态。
Plant Cell. 2020 Feb;32(2):508-524. doi: 10.1105/tpc.19.00541. Epub 2019 Nov 27.
7
Oryza sativa POSITIVE REGULATOR OF IRON DEFICIENCY RESPONSE 2 (OsPRI2) and OsPRI3 are involved in the maintenance of Fe homeostasis.水稻铁高效响应正调控因子 2（OsPRI2）和 OsPRI3 参与铁稳态的维持。
Plant Cell Environ. 2020 Jan;43(1):261-274. doi: 10.1111/pce.13655. Epub 2019 Nov 12.
8
A transcription factor OsbHLH156 regulates Strategy II iron acquisition through localising IRO2 to the nucleus in rice.转录因子 OsbHLH156 通过将 IRO2 定位于细胞核中来调节水稻中的策略 II 铁吸收。
New Phytol. 2020 Feb;225(3):1247-1260. doi: 10.1111/nph.16232. Epub 2019 Nov 1.
9
OsbHLH058 and OsbHLH059 transcription factors positively regulate iron deficiency responses in rice.OsbHLH058 和 OsbHLH059 转录因子正向调控水稻缺铁应答。
Plant Mol Biol. 2019 Nov;101(4-5):471-486. doi: 10.1007/s11103-019-00917-8. Epub 2019 Sep 24.
10
Arabidopsis BRUTUS-LIKE E3 ligases negatively regulate iron uptake by targeting transcription factor FIT for recycling.拟南芥 BRUTUS-LIKE E3 连接酶通过靶向转录因子 FIT 进行循环来负调控铁的摄取。
Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17584-17591. doi: 10.1073/pnas.1907971116. Epub 2019 Aug 14.

bHLH11 通过招募 TOPLESS/TOPLESS 相关的核心抑制蛋白来抑制 bHLH IVc 蛋白。

bHLH11 inhibits bHLH IVc proteins by recruiting the TOPLESS/TOPLESS-RELATED corepressors.

机构信息

CAS Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Kunming, Yunnan 650223, China.

Center of Economic Botany, Core Botanical Gardens, Chinese Academy of Sciences, Mengla, Yunnan 666303, China.

出版信息

Plant Physiol. 2022 Feb 4;188(2):1335-1349. doi: 10.1093/plphys/kiab540.

DOI:10.1093/plphys/kiab540
PMID:34894263
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8825326/
Abstract

Iron (Fe) homeostasis is essential for plant growth and development. Many transcription factors (TFs) play pivotal roles in the maintenance of Fe homeostasis. bHLH11 is a negative TF that regulates Fe homeostasis. However, the underlying molecular mechanism remains elusive. Here, we generated two loss-of-function bhlh11 mutants in Arabidopsis (Arabidopsis thaliana), which display enhanced sensitivity to excess Fe, increased Fe accumulation, and elevated expression of Fe deficiency responsive genes. Levels of bHLH11 protein, localized in both the cytoplasm and nucleus, decreased in response to Fe deficiency. Co-expression assays indicated that bHLH IVc TFs (bHLH34, bHLH104, bHLH105, and bHLH115) facilitate the nuclear accumulation of bHLH11. Further analysis indicated that bHLH11 represses the transactivity of bHLH IVc TFs toward bHLH Ib genes (bHLH38, bHLH39, bHLH100, and bHLH101). The two ethylene response factor-associated amphiphilic repression motifs of bHLH11 provided the repression function by recruiting the TOPLESS/TOPLESS-RELATED (TPL/TPRs) corepressors. Correspondingly, the expression of Fe uptake genes increased in the tpr1 tpr4 tpl mutant. Moreover, genetic analysis revealed that bHLH11 has functions independent of FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR. This study provides insights into the complicated Fe homeostasis signaling network.

摘要

铁（Fe）稳态对于植物的生长和发育至关重要。许多转录因子（TFs）在维持Fe 稳态中起着关键作用。bHLH11 是一种负调控因子，调节 Fe 稳态。然而，其潜在的分子机制仍不清楚。本研究在拟南芥中生成了两个 bhlh11 功能丧失突变体，它们对过量 Fe 表现出更高的敏感性，Fe 积累增加，Fe 缺乏响应基因的表达上调。细胞质和细胞核中定位的 bHLH11 蛋白水平在 Fe 缺乏时降低。共表达分析表明，bHLH IVc TFs（bHLH34、bHLH104、bHLH105 和 bHLH115）促进 bHLH11 的核积累。进一步分析表明，bHLH11 抑制 bHLH IVc TFs 对 bHLH Ib 基因（bHLH38、bHLH39、bHLH100 和 bHLH101）的转录活性。bHLH11 的两个与乙烯反应因子相关的两亲性抑制基序通过募集 TOPLESS/TOPLESS-RELATED（TPL/TPRs）核心抑制子提供抑制功能。相应地，在 tpr1 tpr4 tpl 突变体中，Fe 摄取基因的表达增加。此外，遗传分析表明 bHLH11 具有独立于 FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR 的功能。本研究深入了解了复杂的 Fe 稳态信号网络。