肌苷类似物在培养物中对卡氏肺孢子虫的活性。
Activity of inosine analogs against Pneumocystis carinii in culture.
作者信息
Bartlett M S, Marr J J, Queener S F, Klein R S, Smith J W
出版信息
Antimicrob Agents Chemother. 1986 Jul;30(1):181-3. doi: 10.1128/AAC.30.1.181.
Abstract
Three analogs of inosine, formycin B, allopurinol ribonucleoside, and 9-deazainosine, were tested for their ability to suppress proliferation of Pneumocystis carinii in culture with WI-38 cells. The organism was inhibited by 9-deazainosine at 10 micrograms/ml, and there was some inhibition at 1 microgram/ml. Formycin B was effective only at 40 micrograms/ml. Allopurinol ribonucleoside had little effect.
摘要
对肌苷的三种类似物，即间型霉素B、别嘌呤醇核糖核苷和9-脱氮肌苷，进行了测试，以检验它们在WI-38细胞培养中抑制卡氏肺孢子虫增殖的能力。9-脱氮肌苷在10微克/毫升时可抑制该生物体，在1微克/毫升时有一定抑制作用。间型霉素B仅在40微克/毫升时有效。别嘌呤醇核糖核苷几乎没有作用。
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