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肌苷类似物在培养物中对卡氏肺孢子虫的活性。

Activity of inosine analogs against Pneumocystis carinii in culture.

作者信息

Bartlett M S, Marr J J, Queener S F, Klein R S, Smith J W

出版信息

Antimicrob Agents Chemother. 1986 Jul;30(1):181-3. doi: 10.1128/AAC.30.1.181.

DOI:10.1128/AAC.30.1.181
PMID:3489438
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC176462/
Abstract

Three analogs of inosine, formycin B, allopurinol ribonucleoside, and 9-deazainosine, were tested for their ability to suppress proliferation of Pneumocystis carinii in culture with WI-38 cells. The organism was inhibited by 9-deazainosine at 10 micrograms/ml, and there was some inhibition at 1 microgram/ml. Formycin B was effective only at 40 micrograms/ml. Allopurinol ribonucleoside had little effect.

摘要

对肌苷的三种类似物，即间型霉素B、别嘌呤醇核糖核苷和9-脱氮肌苷，进行了测试，以检验它们在WI-38细胞培养中抑制卡氏肺孢子虫增殖的能力。9-脱氮肌苷在10微克/毫升时可抑制该生物体，在1微克/毫升时有一定抑制作用。间型霉素B仅在40微克/毫升时有效。别嘌呤醇核糖核苷几乎没有作用。

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Activity of inosine analogs against Pneumocystis carinii in culture.肌苷类似物在培养物中对卡氏肺孢子虫的活性。
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2
Pneumocystis carinii pneumonia therapy with 9-deazainosine in rats.用9-去氮肌苷对大鼠进行卡氏肺孢子虫肺炎治疗。
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引用本文的文献

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本文引用的文献

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A NEW ANTIBIOTIC, FORMYCIN.一种新型抗生素——强力霉素
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Effects of 8-azaadenosine and formycin on cell lethality and the synthesis and methylation of nucleic acids in human colon carcinoma cells in culture.8-氮杂腺苷和间型霉素对培养的人结肠癌细胞的细胞致死率以及核酸合成与甲基化的影响。
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Biological action of inosine analogs in Leishmania and Trypanosoma spp.肌苷类似物在利什曼原虫和锥虫属中的生物学作用
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Adverse reactions to trimethoprim-sulfamethoxazole in patients with the acquired immunodeficiency syndrome.获得性免疫缺陷综合征患者对甲氧苄啶-磺胺甲恶唑的不良反应。
Ann Intern Med. 1984 Apr;100(4):495-9. doi: 10.7326/0003-4819-100-4-495.
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Pyrazolopyrimidine metabolism in the pathogenic trypanosomatidae.致病锥虫科中吡唑并嘧啶的代谢
Mol Biochem Parasitol. 1983 Apr;7(4):339-56. doi: 10.1016/0166-6851(83)90016-6.
8
Metabolism of formycin B by Leishmania amastigotes in vitro. Comparative metabolism in infected and uninfected human macrophages.利什曼原虫无鞭毛体在体外对间型霉素B的代谢。感染与未感染人类巨噬细胞中的代谢比较
J Exp Med. 1983 Jul 1;158(1):252-7. doi: 10.1084/jem.158.1.252.
9
Stereochemical analysis of the specificity of pancreatic RNAse with polyformycin as substrate: differentiation of the transphosphorylation and hydrolysis reactions.以多聚霉素为底物对胰腺核糖核酸酶特异性的立体化学分析：转磷酸化反应与水解反应的区分
Proc Natl Acad Sci U S A. 1969 Feb;62(2):581-8. doi: 10.1073/pnas.62.2.581.
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Studies on formycin and formycin B in cells of Ehrlich carcinoma and E. coli.关于氮杂环丙啶和氮杂环丙啶B在艾氏腹水癌细胞和大肠杆菌细胞中的研究。
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