肌苷类似物在利什曼原虫和锥虫属中的生物学作用
Biological action of inosine analogs in Leishmania and Trypanosoma spp.
作者信息
Marr J J, Berens R L, Cohn N K, Nelson D J, Klein R S
出版信息
Antimicrob Agents Chemother. 1984 Feb;25(2):292-5. doi: 10.1128/AAC.25.2.292.
Abstract
Previous investigations have suggested that inosine analogs would be good models for the development of chemotherapeutic agents active against pathogenic hemoflagellates. We have systematically modified the five-membered heterocyclic ring of six inosine analogs and tested them for their antiprotozoal activities and toxicity to a mammalian cell line. All six analogs were very active against the three protozoan pathogens Leishmania donovani, Trypanosoma cruzi, and Trypanosoma gambiense. Two of the six, 9-deazainosine and allopurinol ribonucleoside, had very little toxicity for mouse L cells and offer promise as potential chemotherapeutic agents.
摘要
先前的研究表明，肌苷类似物将是开发对致病性血鞭毛虫有效的化疗药物的良好模型。我们系统地修饰了六种肌苷类似物的五元杂环，并测试了它们的抗原生动物活性和对哺乳动物细胞系的毒性。所有六种类似物对三种原生动物病原体杜氏利什曼原虫、克氏锥虫和冈比亚锥虫都非常有效。六种中的两种，即9-脱氮肌苷和别嘌呤醇核糖核苷，对小鼠L细胞的毒性很小，有望成为潜在的化疗药物。
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本文引用的文献
1
A NEW ANTIBIOTIC, FORMYCIN.一种新型抗生素——强力霉素
J Antibiot (Tokyo). 1964 May;17:96-9.
2
Phosphorylation and anti-leishmanial activity of formycin B.间型霉素B的磷酸化作用及抗利什曼原虫活性
Biochem Biophys Res Commun. 1981 Jun 16;100(3):1377-83. doi: 10.1016/0006-291x(81)91976-8.
3
Effects of 8-azaadenosine and formycin on cell lethality and the synthesis and methylation of nucleic acids in human colon carcinoma cells in culture.8-氮杂腺苷和间型霉素对培养的人结肠癌细胞的细胞致死率以及核酸合成与甲基化的影响。
Biochem Pharmacol. 1982 Oct 15;31(20):3207-14. doi: 10.1016/0006-2952(82)90551-2.
4
The metabolism of formycin B in Leishmania donovani.杜氏利什曼原虫中助间型霉素B的代谢
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Biochem Pharmacol. 1982 Jan 15;31(2):143-8. doi: 10.1016/0006-2952(82)90203-9.
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Antimicrob Agents Chemother. 1982 Oct;22(4):657-61. doi: 10.1128/AAC.22.4.657.
7
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8
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9
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10
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